ID   TM130_PONAB             Reviewed;         423 AA.
AC   Q5R6F5;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Transmembrane protein 130;
DE   Flags: Precursor;
GN   Name=TMEM130;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC       pass type I membrane protein {ECO:0000250}.
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DR   EMBL; CR860535; CAH92661.1; -; mRNA.
DR   RefSeq; NP_001126556.1; NM_001133084.1.
DR   AlphaFoldDB; Q5R6F5; -.
DR   STRING; 9601.ENSPPYP00000019456; -.
DR   GeneID; 100173547; -.
DR   KEGG; pon:100173547; -.
DR   CTD; 222865; -.
DR   eggNOG; ENOG502QSPZ; Eukaryota.
DR   InParanoid; Q5R6F5; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR045219; PKAT.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   PANTHER; PTHR11861; PTHR11861; 1.
DR   SUPFAM; SSF49299; SSF49299; 2.
DR   PROSITE; PS50093; PKD; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..423
FT                   /note="Transmembrane protein 130"
FT                   /id="PRO_0000278278"
FT   TOPO_DOM        25..339
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        361..423
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          147..233
FT                   /note="PKD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00151"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        197
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        300
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   423 AA;  47062 MW;  496E6709496179DF CRC64;
     MAQAVWSRLG RILWLSCLLP WAPAGVAAGL YELNLTTDSP ATTGAEVTIS ASLVAKDNGS
     LALPADAHLY RFHWIHTPLV LTGKAEKGLS STIRVVGHVP GEFPVSVWVT ASDCWMCQPV
     ARGFVVLHIT EFLVGDLVVT QNTSLPWPSS YLTKTILKVS FLLHDPSDFL KTALFLYSWD
     FGDGTQMVTE DSVVYYNYSI IGTFTVKLKV VAEWEEVKPD ATKAVMQKTG DFSASLKLQE
     TLRGIQVLGP TLIQTFQKMT LTLNFLGSPP LTVCWRLKPE CLPLEEGECH PVSVASTAYN
     LTHTFRDPGD YCFSIRAENI ISKTHQYHRI QVWPSRIQPA VFAFPCATLI TVMLAFIMYM
     TLRNATQQKD MVENPEPPSG VRCCCQMCCG PFLLETPSEY LEIVRENHGL LPPLYKSVKT
     YTV