TM131_DROME
ID TM131_DROME Reviewed; 1567 AA.
AC Q9V7H4; Q0IGX2; Q960K9;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2002, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Transmembrane protein 131 homolog;
DE Flags: Precursor;
GN ORFNames=CG8370;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Farfan D., Frise E., George R.A., Gonzalez M.,
RA Guarin H., Kapadia B., Li P.W., Liao G., Miranda A., Mungall C.J.,
RA Nunoo J., Pacleb J.M., Paragas V., Park S., Phouanenavong S., Wan K.H.,
RA Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1201 AND SER-1258, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM131 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK93430.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE013599; AAF58081.2; -; Genomic_DNA.
DR EMBL; AY052006; AAK93430.1; ALT_SEQ; mRNA.
DR EMBL; BT028798; ABI34179.1; -; mRNA.
DR RefSeq; NP_001286471.1; NM_001299542.1.
DR RefSeq; NP_611073.2; NM_137229.3.
DR AlphaFoldDB; Q9V7H4; -.
DR IntAct; Q9V7H4; 1.
DR STRING; 7227.FBpp0086345; -.
DR GlyGen; Q9V7H4; 13 sites.
DR iPTMnet; Q9V7H4; -.
DR PaxDb; Q9V7H4; -.
DR PRIDE; Q9V7H4; -.
DR EnsemblMetazoa; FBtr0087203; FBpp0086345; FBgn0034060.
DR EnsemblMetazoa; FBtr0340015; FBpp0309029; FBgn0034060.
DR GeneID; 36761; -.
DR KEGG; dme:Dmel_CG8370; -.
DR UCSC; CG8370-RA; d. melanogaster.
DR FlyBase; FBgn0034060; CG8370.
DR VEuPathDB; VectorBase:FBgn0034060; -.
DR eggNOG; KOG3620; Eukaryota.
DR GeneTree; ENSGT00530000063614; -.
DR HOGENOM; CLU_245976_0_0_1; -.
DR InParanoid; Q9V7H4; -.
DR OMA; EGPQNLW; -.
DR OrthoDB; 40890at2759; -.
DR PhylomeDB; Q9V7H4; -.
DR BioGRID-ORCS; 36761; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 36761; -.
DR PRO; PR:Q9V7H4; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034060; Expressed in embryonic/larval hemocyte (Drosophila) and 25 other tissues.
DR ExpressionAtlas; Q9V7H4; baseline and differential.
DR Genevisible; Q9V7H4; DM.
DR GO; GO:0012505; C:endomembrane system; HDA:FlyBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR039877; TMEM131-like.
DR InterPro; IPR045695; TMEM131-like_conserved.
DR InterPro; IPR022113; TMEM131-like_N.
DR PANTHER; PTHR22050; PTHR22050; 1.
DR Pfam; PF19532; TMEM131_like; 1.
DR Pfam; PF12371; TMEM131_like_N; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..1567
FT /note="Transmembrane protein 131 homolog"
FT /id="PRO_0000097537"
FT TOPO_DOM 33..1049
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1050..1070
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1071..1567
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1112..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1364..1386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1502..1567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1096..1130
FT /evidence="ECO:0000255"
FT COMPBIAS 1128..1154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1281..1298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1319..1337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1365..1386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1506..1523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1538..1567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1201
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1258
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 235
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 316
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 317
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 342
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 372
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 409
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 462
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 563
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 890
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1013
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1567 AA; 173321 MW; 8247D90728D90801 CRC64;
MPTQVQMRPL LRIFAEPILL ILIFLFTLGA KGEKVLQETF LGLQEAPIHD LGDLRLVPSR
LDFGTWSVGQ ARSQTVTLFN QHSNRTLQLN AVAGPSPAFY SSFLGTREVP PQGNTTFNVV
FLPRQLGAIA ADLLIHTSFG QAELAVQGEG SECPYRLKPL VGIKAPMNAT LTPEIHMYNP
HERPLQILEI YSSGGEFQLE LPSGGSEGPQ NLWKIPPHTL KPVIRISFHG RTAGNHSAYI
RIKVAEQELD IFIPVEFEIL PRHSVYARNP LADFGRVATL NAPDALQFKL DVRNDESRQL
FGSYLRQIPG LSFDANNTSI VLDASLFEGD EIINDLLVIN SNQSSTSPGA DQPFTVLVRA
EIFHGGLTFD RNATRFVTTS PEGVEGEPLE RKRSLVVRNK FAIPLMLFNV SLTEPIDESI
LEVTLVGDPR ILIQPDESVE LLRLNLLNDQ VPFKSFLRIE TNVTVFKLPL VSCSGRLHVS
TQPIVLNFRQ ESLEKAAYNL ELDLGTVPFA EMSRDGFVIL RNDNPVPVRI TNWFFKHPKT
VYSQSTFLGC RATAIGHPVS VENDTKGWHL CTEIRAGESA VFKVAIQTYE ADATFGTLKV
WTPYEVIRVR VKFEASVGHL EIDQEQLSFK NCFPGKMCTA VLSIRSSFTH PVHVKGISFA
LPVGLRFKDF NAKGTTIAPQ TLTKVGRIYF DPASVCRNNC YIRESTNDLA IFPSVPGGGN
GNSGVINNNL LYDGVELRQR TELFRQLRRQ LSSMSLTLHS EELPPLELDF SITIEWPKLV
QFQPIPPTPA IEVGQVQRQW ITLTNPSQSP LLLDYFLSDP AFARRTQLSL PHEVIDVSST
SCYLTDKEVF SLPEAGDPIL LPGGASLTIP ITFSAQLPEK YCTLLHVRSN LTLYEAVWLQ
ARAVQSQFRF GNRRPGAASP LLFEMATNQF QGCQSGNEAV VVTRSFTARN SGVIPIRIEG
FLIGSLPCED FGFKVMDCAG FDLGENEARK VEIAFSADFT TSAVKRSLTL LTNLTYDISY
KLLAQMPAES VELCASLLVR PGWESSLKNA ALVVLLASFG LVLVAAVFDA KAIMVQQNAY
DAARNKGPLQ PTFNLRNIVK LQAEEAAAKA ESVQQQQKVK NGQLKELRKR TVVNSTNSKS
KSKSSWSPWS MDMNALSKHL QKAKPKTVVS TPVTPPAASA PAAAPVPLPE AKPVKKSSTP
SPQGVPISVQ VRPQKKVKPT PAVVLGTTKP KQEVSTPVAD QHEKSLAKSS PPQQENISPK
PNKPPEQRVL KEQNGSAKKM GKTPGRERER ERRSKDQKLT NGTGAGVGFR KPERKQRQKL
NFGQTTNSTS PPESPDALKC ISNPWETSSR VSFRDVLRTP QMAPTDNGFD WNHATSSSDL
GPIGDNRKNA TPPMVTSLWE PLSATASNSL FANTEVDFIT PDAIYEQRER EKPQWEQRSD
LVMRQQLLLQ QPQKLEFQLR QQEKISLLAN MDPSNWATNW SPLGYSTWPN ATAGIGVMRP
PPGLEQSARQ THNLAQEQVS AGPASGTGAA LHGESLPTQY DPFTSPSSIW SDTWRQSSQR
NNHNHMN
