TM131_MOUSE
ID TM131_MOUSE Reviewed; 1877 AA.
AC O70472; Q8CHH3;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Transmembrane protein 131;
DE AltName: Full=Protein RW1;
GN Name=Tmem131; Synonyms=D1Bwg0491e, Kiaa0257, Rw1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 54-1877.
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=10996388; DOI=10.1016/s0165-2478(00)00239-x;
RA Tscharke D.C., Wilkinson R., Simmons A.;
RT "Use of mRNA differential display to study the action of lymphocyte subsets
RT in vivo and application to a murine model of herpes simplex virus
RT infection.";
RL Immunol. Lett. 74:127-132(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-1877.
RC TISSUE=Brain;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: I.
RT The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in the immune response to viral infection.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM131 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC15232.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
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DR EMBL; AC084389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC123854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF060565; AAC15232.1; ALT_SEQ; mRNA.
DR EMBL; AB093221; BAC41405.1; -; mRNA.
DR CCDS; CCDS35538.1; -.
DR PIR; T14280; T14280.
DR RefSeq; NP_061360.2; NM_018872.2.
DR AlphaFoldDB; O70472; -.
DR BioGRID; 207783; 3.
DR STRING; 10090.ENSMUSP00000027290; -.
DR GlyConnect; 2788; 4 N-Linked glycans (2 sites).
DR GlyGen; O70472; 2 sites, 4 N-linked glycans (2 sites).
DR iPTMnet; O70472; -.
DR PhosphoSitePlus; O70472; -.
DR EPD; O70472; -.
DR jPOST; O70472; -.
DR MaxQB; O70472; -.
DR PaxDb; O70472; -.
DR PeptideAtlas; O70472; -.
DR PRIDE; O70472; -.
DR ProteomicsDB; 259526; -.
DR Antibodypedia; 9002; 23 antibodies from 9 providers.
DR DNASU; 56030; -.
DR Ensembl; ENSMUST00000027290; ENSMUSP00000027290; ENSMUSG00000026116.
DR Ensembl; ENSMUST00000194563; ENSMUSP00000142307; ENSMUSG00000026116.
DR GeneID; 56030; -.
DR KEGG; mmu:56030; -.
DR UCSC; uc007ard.1; mouse.
DR CTD; 23505; -.
DR MGI; MGI:1927110; Tmem131.
DR VEuPathDB; HostDB:ENSMUSG00000026116; -.
DR eggNOG; KOG3620; Eukaryota.
DR GeneTree; ENSGT00530000063614; -.
DR HOGENOM; CLU_002491_1_1_1; -.
DR InParanoid; O70472; -.
DR OMA; EGPQNLW; -.
DR OrthoDB; 45814at2759; -.
DR PhylomeDB; O70472; -.
DR TreeFam; TF321435; -.
DR BioGRID-ORCS; 56030; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Tmem131; mouse.
DR PRO; PR:O70472; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; O70472; protein.
DR Bgee; ENSMUSG00000026116; Expressed in late embryo and 262 other tissues.
DR ExpressionAtlas; O70472; baseline and differential.
DR Genevisible; O70472; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR039877; TMEM131-like.
DR InterPro; IPR045695; TMEM131-like_conserved.
DR InterPro; IPR022113; TMEM131-like_N.
DR PANTHER; PTHR22050; PTHR22050; 1.
DR Pfam; PF19532; TMEM131_like; 2.
DR Pfam; PF12371; TMEM131_like_N; 1.
PE 2: Evidence at transcript level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1877
FT /note="Transmembrane protein 131"
FT /id="PRO_0000097539"
FT TRANSMEM 1089..1109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1116..1136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1197..1573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1590..1655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1679..1707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1830..1852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1321
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1329..1362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1364..1379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1388..1418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1431..1472
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1485..1523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1535..1554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1607..1648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1830..1845
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1318
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q92545"
FT MOD_RES 1338
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q92545"
FT MOD_RES 1371
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q92545"
FT MOD_RES 1857
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q92545"
FT MOD_RES 1865
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q92545"
FT CONFLICT 488
FT /note="V -> A (in Ref. 2; AAC15232)"
FT /evidence="ECO:0000305"
FT CONFLICT 750
FT /note="C -> R (in Ref. 2; AAC15232)"
FT /evidence="ECO:0000305"
FT CONFLICT 776
FT /note="D -> N (in Ref. 2; AAC15232)"
FT /evidence="ECO:0000305"
FT CONFLICT 935
FT /note="S -> F (in Ref. 3; BAC41405)"
FT /evidence="ECO:0000305"
FT CONFLICT 1790
FT /note="S -> R (in Ref. 3; BAC41405)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1877 AA; 204651 MW; DADE201489DEF45B CRC64;
MGKRAGGAAA AAAAASTSSA AGLEPAAGRG GGPRSAAAGL LGALHLVMTL VVAAARAEKE
AFIQSESIIE VLRFDDGGLL QTETTLGLGS YQQKSISLYR GNCRPIRFEP PMLDFHEQPV
GMPKMEKVYL HNPSSEETIT LVSISATTSH FHASFFQNRK ILPGGNTSFD VVFLARVVGN
VENTLFINTS NHGVFTYQVF GVGVPNPYRL RPFLGARVPV NSSFSPIINI HNPHSEPLQV
VEMYSSGGDL HLELPTGQQG GTRKLWEIPP YETKGVMRAS FSSREADNHT AFIRIKTNAS
DSTEFIILPV EVEVTTAPGI YSSTEMLDFG TLRTQDLPKV LNLHLLNSGT KDVPITSVRP
TPQNDAITVH FKPVTLKASE SKYTKVASIS FDASRAKKPS QFSGKITVKA KEKSYSKLEI
PYQAEVLDGY LGFDHAATLF HIQDSPADPV ERPIYLTNTF SFAILIHDVL LPEEARIMFQ
VHNFSQPVLI LPNESGYIFT LFFMPSTSSM HIDNNILLVT NASKFHLPVR VYTGFLDYFV
LPPKIEERFI DFGVLSATEA SSILFAIINS NPIELAIKSW HIIGDGLSIE LVATERGNRS
TVIASLPELE RSSLPDQSPV TLASGHFAVF RVKLTAKKLE GVHDGAIQIT TDYEILTIPV
KAVIAVGSLT CFPKHMVLPP SFPGKIVHQS LNIMNSFSQK VKIQQIRSLS EDVRFYYKRL
RGNREDLEPG KKSKIANIYF DPGLQCGDHC YIGLPFLSKS EPKVQPGVAM QEDLWDADWD
AHQSLFKAWM GIKENAGHRL NAMFEVNTDL QKNIVSKVSA ELSWPSVLSS PRLLKFPLTN
TNCSSEEEIS LENPADVPVY VQFIPLALYS NPSVFADKLV SRFNLSKVAK LDLRTLEFQV
YRNSAHPLQS PTGFTEGLSR HFILNLILKP GEKKSVKVKF TPLHNRTVSS LIIVRNNLTV
MDAVMVQGQG TTENLRVAGK LPGPGSSLRF KITEALLKDC IDRLKLREPN FTLKRTFKVE
NTGQLEIRVE TIEISGYACE GYGFKVVNCQ EFALSANASR DIVILFTPDF TASRVIRELK
FVTSSGSEFV FVLNASLPYH MLAACAEALP RPNWELALYI IISGVMSALF LLVIGTAYLE
AQGIWEPFRR RLSFEASNPP FDVGRPFDLR RIVGISSEGN LNTLGCEHSH GRGFYSNASS
RPGTGSHRQC GTSVHPHSSH GSKNSADVDN VRTRNSSSMS SRTSPQAAAS QSTSKTSPLV
SETAAATQGH TASRKSRGAK QGQHSSQHHS HSHSPLEQHS QPPPPVPQHQ EPPPERLSPA
PLTHPSHPER ASTTRHSSED SDITSLIEAM DKDFDHHDSS PLDVFTEQPP SPMSKSKGKG
KSLQQRKAKP PKKQEEKEKR GKGKPQEDEL KDALADDDSS STTTETSNPD TEPLLREDTE
KHKGRPAVPE KQESELSQGK PKSKKLLNAK KEIPTDVKGS SFELPYTPSL ENKQRRNLPT
KIPLPTTLAS GSKSRNPPKT KGTNKLVENR PVALSKFLPS SQELGNTSSS EGEKDSPPPE
WDAVPVHKPS SSTDSLYKLS LQTLNADIFL KQRQTSPTPA SPSLPTAPCP FTSRGSYSSV
VNSSGSDTKA KQTSSSKSKL TKAASLPGKN GNPTFAAVAA GYDKSPGGNG FAKISSNKSD
FSSSLGISHI PVDSDGSDSS GLWSPVSNPN SPDFTPLNSF SAFGNSFNLT GAVFSKLSRS
CSQSSQRSWN EFNSGPSYLW DSPATDPSPS WPASSSSPTH TATSILGNSS GLWSTTPFSS
SIWSSNINSN LPFSTPTNAL SSISLMGTEN SAAAHTPSAS GPADDLGQTY NPWRIWSPTV
GRRSSDPWSN SHFPHEN
