TM134_BOVIN
ID TM134_BOVIN Reviewed; 195 AA.
AC Q05B54;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Transmembrane protein 134;
GN Name=TMEM134;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Endometrium;
RA Renard J.P., Lewin H.A., Yang J., Hernandez A., Sandra O., Everts R.E.,
RA Hue I.;
RT "Endometrium ESTs (bcbp).";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Cytoplasm, perinuclear region
CC {ECO:0000250|UniProtKB:Q9H6X4}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q05B54-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q05B54-2; Sequence=VSP_023451;
CC -!- SIMILARITY: Belongs to the TMEM134/TMEM230 family. {ECO:0000305}.
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DR EMBL; CR849934; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC122796; AAI22797.1; -; mRNA.
DR RefSeq; NP_001073723.1; NM_001080254.2. [Q05B54-2]
DR RefSeq; XP_005227098.1; XM_005227041.2.
DR AlphaFoldDB; Q05B54; -.
DR PaxDb; Q05B54; -.
DR PRIDE; Q05B54; -.
DR GeneID; 510129; -.
DR KEGG; bta:510129; -.
DR CTD; 80194; -.
DR eggNOG; KOG4753; Eukaryota.
DR HOGENOM; CLU_120539_0_0_1; -.
DR InParanoid; Q05B54; -.
DR OrthoDB; 1469582at2759; -.
DR TreeFam; TF323560; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR039714; TMEM134.
DR InterPro; IPR008590; TMEM_230/134.
DR PANTHER; PTHR13558; PTHR13558; 1.
DR Pfam; PF05915; TMEM_230_134; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..195
FT /note="Transmembrane protein 134"
FT /id="PRO_0000279484"
FT TOPO_DOM 1..122
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..154
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..195
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 60..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 93
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R0J4"
FT VAR_SEQ 136..150
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_023451"
FT CONFLICT 194
FT /note="E -> V (in Ref. 1; CR849934)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 195 AA; 21567 MW; 887C1872E8A40D31 CRC64;
MSASRPQFSI DDAFELSLED TGPGLEPSGV ARFGPLHFER RARFEVADED KQSRLRYQNL
ENDEDGAQAS PEPDGGVSSR DSGQTSIRSS QWSFSSISSS TQRSYNACCS WTQHPLIQKN
HRVVLASFLL LLLGLVLILT GVGLEVAPSP GVSSAIFFVP GFLLLVPGVY HVIFIYCAVK
GHRGFQFFYL PYFEK
