TM134_HUMAN
ID TM134_HUMAN Reviewed; 195 AA.
AC Q9H6X4; Q08AK4; Q6PJN3;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transmembrane protein 134;
GN Name=TMEM134;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH HEV VIRUS ORF2.
RX PubMed=27899274; DOI=10.1016/j.virusres.2016.11.027;
RA Tian Y., Huang W., Yang J., Wen Z., Geng Y., Zhao C., Zhang H., Wang Y.;
RT "Systematic identification of hepatitis E virus ORF2 interactome reveals
RT that TMEM134 engages in ORF2-mediated NF-kappaB pathway.";
RL Virus Res. 228:102-108(2017).
CC -!- SUBUNIT: (Microbial infection) Interacts with Hepatitis E virus (HEV)
CC ORF2. {ECO:0000269|PubMed:27899274}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Cytoplasm, perinuclear region
CC {ECO:0000269|PubMed:27899274}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9H6X4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H6X4-2; Sequence=VSP_023452;
CC Name=3;
CC IsoId=Q9H6X4-3; Sequence=VSP_023453, VSP_023454;
CC -!- SIMILARITY: Belongs to the TMEM134/TMEM230 family. {ECO:0000305}.
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DR EMBL; AK025402; BAB15126.1; -; mRNA.
DR EMBL; BC013883; AAH13883.1; -; mRNA.
DR EMBL; BC125134; AAI25135.1; -; mRNA.
DR CCDS; CCDS41678.1; -. [Q9H6X4-2]
DR CCDS; CCDS8167.1; -. [Q9H6X4-1]
DR RefSeq; NP_001072118.1; NM_001078650.2. [Q9H6X4-2]
DR RefSeq; NP_001072119.1; NM_001078651.2.
DR RefSeq; NP_079400.1; NM_025124.3. [Q9H6X4-1]
DR AlphaFoldDB; Q9H6X4; -.
DR BioGRID; 123167; 17.
DR IntAct; Q9H6X4; 4.
DR STRING; 9606.ENSP00000312615; -.
DR TCDB; 9.B.232.1.8; the parkinson's disease tmem230 (tmem230) family.
DR iPTMnet; Q9H6X4; -.
DR PhosphoSitePlus; Q9H6X4; -.
DR SwissPalm; Q9H6X4; -.
DR BioMuta; TMEM134; -.
DR DMDM; 74718574; -.
DR EPD; Q9H6X4; -.
DR jPOST; Q9H6X4; -.
DR MassIVE; Q9H6X4; -.
DR MaxQB; Q9H6X4; -.
DR PaxDb; Q9H6X4; -.
DR PeptideAtlas; Q9H6X4; -.
DR PRIDE; Q9H6X4; -.
DR ProteomicsDB; 81052; -. [Q9H6X4-1]
DR ProteomicsDB; 81053; -. [Q9H6X4-2]
DR ProteomicsDB; 81054; -. [Q9H6X4-3]
DR Antibodypedia; 30426; 69 antibodies from 14 providers.
DR DNASU; 80194; -.
DR Ensembl; ENST00000308022.7; ENSP00000312615.2; ENSG00000172663.9. [Q9H6X4-1]
DR Ensembl; ENST00000393877.3; ENSP00000377455.3; ENSG00000172663.9. [Q9H6X4-2]
DR Ensembl; ENST00000545682.5; ENSP00000438439.1; ENSG00000172663.9. [Q9H6X4-3]
DR GeneID; 80194; -.
DR KEGG; hsa:80194; -.
DR MANE-Select; ENST00000308022.7; ENSP00000312615.2; NM_025124.4; NP_079400.1.
DR UCSC; uc001olq.3; human. [Q9H6X4-1]
DR CTD; 80194; -.
DR DisGeNET; 80194; -.
DR GeneCards; TMEM134; -.
DR HGNC; HGNC:26142; TMEM134.
DR HPA; ENSG00000172663; Low tissue specificity.
DR neXtProt; NX_Q9H6X4; -.
DR OpenTargets; ENSG00000172663; -.
DR PharmGKB; PA143485657; -.
DR VEuPathDB; HostDB:ENSG00000172663; -.
DR eggNOG; KOG4753; Eukaryota.
DR GeneTree; ENSGT00390000011766; -.
DR HOGENOM; CLU_1427558_0_0_1; -.
DR InParanoid; Q9H6X4; -.
DR OMA; NTTQRSY; -.
DR OrthoDB; 1365914at2759; -.
DR PhylomeDB; Q9H6X4; -.
DR TreeFam; TF323560; -.
DR PathwayCommons; Q9H6X4; -.
DR SignaLink; Q9H6X4; -.
DR BioGRID-ORCS; 80194; 15 hits in 1087 CRISPR screens.
DR ChiTaRS; TMEM134; human.
DR GenomeRNAi; 80194; -.
DR Pharos; Q9H6X4; Tdark.
DR PRO; PR:Q9H6X4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H6X4; protein.
DR Bgee; ENSG00000172663; Expressed in lower esophagus mucosa and 198 other tissues.
DR ExpressionAtlas; Q9H6X4; baseline and differential.
DR Genevisible; Q9H6X4; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
DR InterPro; IPR039714; TMEM134.
DR InterPro; IPR008590; TMEM_230/134.
DR PANTHER; PTHR13558; PTHR13558; 1.
DR Pfam; PF05915; TMEM_230_134; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Host-virus interaction; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..195
FT /note="Transmembrane protein 134"
FT /id="PRO_0000279485"
FT TOPO_DOM 1..122
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..154
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..195
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 93
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R0J4"
FT VAR_SEQ 136..150
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023452"
FT VAR_SEQ 136
FT /note="V -> GPAQCLALETELGELPGEGLCLGHLQLRWWVSRAGGGSPRPHHCSCP
FT HPRGSVCVQC (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023453"
FT VAR_SEQ 137..195
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023454"
SQ SEQUENCE 195 AA; 21586 MW; D20FFFF9531DA68A CRC64;
MSAARPQFSI DDAFELSLED GGPGPESSGV ARFGPLHFER RARFEVADED KQSRLRYQNL
ENDEDGAQAS PEPDGGVGTR DSSRTSIRSS QWSFSTISSS TQRSYNTCCS WTQHPLIQKN
RRVVLASFLL LLLGLVLILV GVGLEATPSP GVSSAIFFVP GFLLLVPGVY HVIFIYCAVK
GHRGFQFFYL PYFEK
