TM134_MOUSE
ID TM134_MOUSE Reviewed; 195 AA.
AC Q8R0J4; Q3TLG9; Q8C1M3; Q9CR66;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Transmembrane protein 134;
GN Name=Tmem134;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J;
RC TISSUE=Embryonic stem cell, Kidney, Mammary gland, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Cytoplasm, perinuclear region
CC {ECO:0000250|UniProtKB:Q9H6X4}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8R0J4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R0J4-2; Sequence=VSP_023456;
CC Name=3;
CC IsoId=Q8R0J4-3; Sequence=VSP_023455;
CC -!- SIMILARITY: Belongs to the TMEM134/TMEM230 family. {ECO:0000305}.
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DR EMBL; AK002220; BAB21944.1; -; mRNA.
DR EMBL; AK009745; BAB26475.1; -; mRNA.
DR EMBL; AK010323; BAC25290.1; -; mRNA.
DR EMBL; AK166519; BAE38823.1; -; mRNA.
DR EMBL; BC026765; AAH26765.1; -; mRNA.
DR RefSeq; NP_001072117.1; NM_001078649.1. [Q8R0J4-1]
DR RefSeq; NP_080165.1; NM_025889.2. [Q8R0J4-2]
DR AlphaFoldDB; Q8R0J4; -.
DR iPTMnet; Q8R0J4; -.
DR PhosphoSitePlus; Q8R0J4; -.
DR SwissPalm; Q8R0J4; -.
DR jPOST; Q8R0J4; -.
DR MaxQB; Q8R0J4; -.
DR PeptideAtlas; Q8R0J4; -.
DR PRIDE; Q8R0J4; -.
DR ProteomicsDB; 260675; -. [Q8R0J4-1]
DR ProteomicsDB; 260676; -. [Q8R0J4-2]
DR ProteomicsDB; 260677; -. [Q8R0J4-3]
DR Antibodypedia; 30426; 69 antibodies from 14 providers.
DR DNASU; 66990; -.
DR Ensembl; ENSMUST00000139987; ENSMUSP00000159417; ENSMUSG00000024845. [Q8R0J4-3]
DR Ensembl; ENSMUST00000140267; ENSMUSP00000159415; ENSMUSG00000024845. [Q8R0J4-1]
DR Ensembl; ENSMUST00000150627; ENSMUSP00000158987; ENSMUSG00000024845. [Q8R0J4-2]
DR Ensembl; ENSMUST00000169055; ENSMUSP00000159412; ENSMUSG00000024845. [Q8R0J4-2]
DR GeneID; 66990; -.
DR KEGG; mmu:66990; -.
DR UCSC; uc008fyr.1; mouse. [Q8R0J4-1]
DR UCSC; uc008fys.1; mouse. [Q8R0J4-2]
DR CTD; 80194; -.
DR MGI; MGI:1914240; Tmem134.
DR VEuPathDB; HostDB:ENSMUSG00000024845; -.
DR GeneTree; ENSGT00390000011766; -.
DR InParanoid; Q8R0J4; -.
DR OrthoDB; 1469582at2759; -.
DR PhylomeDB; Q8R0J4; -.
DR BioGRID-ORCS; 66990; 0 hits in 17 CRISPR screens.
DR ChiTaRS; Tmem134; mouse.
DR PRO; PR:Q8R0J4; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8R0J4; protein.
DR Bgee; ENSMUSG00000024845; Expressed in lip and 172 other tissues.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR InterPro; IPR039714; TMEM134.
DR InterPro; IPR008590; TMEM_230/134.
DR PANTHER; PTHR13558; PTHR13558; 1.
DR Pfam; PF05915; TMEM_230_134; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..195
FT /note="Transmembrane protein 134"
FT /id="PRO_0000279486"
FT TOPO_DOM 1..122
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..154
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..195
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 14..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 93
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 80..88
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_023455"
FT VAR_SEQ 136..150
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_023456"
FT CONFLICT 66
FT /note="G -> R (in Ref. 1; BAE38823)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 195 AA; 21637 MW; D34CCCC924937662 CRC64;
MSAARPQFSI DDAFELTLED AGPEPESSGV ARFGPLHFER RARFEVADED KQSRLRYQNL
ENDEDGAQAS PEPDGGVSTR DSGHMSVRSS QWSFSTISSS TQRSYNACCS WTQHPLIQKN
RRVVLASFLL LLLGLVLILV GVGLEVAPSP GVSSAIFFVP GILLLVPGVY HVIFIYCAVK
GRRGFQFFYL PYFEK
