ID   TM135_BOVIN             Reviewed;         458 AA.
AC   Q3ZBE6;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Transmembrane protein 135 {ECO:0000250|UniProtKB:Q86UB9};
GN   Name=TMEM135 {ECO:0000250|UniProtKB:Q86UB9};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in mitochondrial metabolism by regulating the
CC       balance between mitochondrial fusion and fission. May act as a
CC       regulator of mitochondrial fission that promotes DNM1L-dependent
CC       fission through activation of DNM1L. May be involved in peroxisome
CC       organization. {ECO:0000250|UniProtKB:Q5U4F4,
CC       ECO:0000250|UniProtKB:Q9CYV5}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:Q9CYV5}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9CYV5}. Peroxisome membrane
CC       {ECO:0000250|UniProtKB:Q9CYV5}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM135 family. {ECO:0000305}.
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DR   EMBL; BC103393; AAI03394.1; -; mRNA.
DR   RefSeq; NP_001030425.1; NM_001035348.1.
DR   AlphaFoldDB; Q3ZBE6; -.
DR   STRING; 9913.ENSBTAP00000007209; -.
DR   PaxDb; Q3ZBE6; -.
DR   PRIDE; Q3ZBE6; -.
DR   Ensembl; ENSBTAT00000085727; ENSBTAP00000074445; ENSBTAG00000005482.
DR   GeneID; 523885; -.
DR   KEGG; bta:523885; -.
DR   CTD; 65084; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005482; -.
DR   VGNC; VGNC:56288; TMEM135.
DR   eggNOG; KOG1398; Eukaryota.
DR   GeneTree; ENSGT00390000000303; -.
DR   InParanoid; Q3ZBE6; -.
DR   OMA; TDKCVNA; -.
DR   OrthoDB; 706534at2759; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000005482; Expressed in liver and 106 other tissues.
DR   ExpressionAtlas; Q3ZBE6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0090140; P:regulation of mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:0009409; P:response to cold; IEA:Ensembl.
DR   GO; GO:0032094; P:response to food; IEA:Ensembl.
DR   InterPro; IPR026749; Tmem135.
DR   InterPro; IPR031926; TMEM135_N.
DR   PANTHER; PTHR12459; PTHR12459; 1.
DR   Pfam; PF15982; TMEM135_C_rich; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Peroxisome; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..458
FT                   /note="Transmembrane protein 135"
FT                   /id="PRO_0000284621"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   458 AA;  52269 MW;  1BE533F51C669A4F CRC64;
     MAALSKSIPH NCYEIGHTWQ PSCWLSFLHI TRGALEESLK IYAPLYLIAA ILRKRKLDYY
     LHKLLPEILQ SASFLTANGA LFMAFFCILR KILGKFYLWS PGFGAALPAS YVAILVERKS
     RRGLLTIYMA NLATETLFRM GVARGVITTL RNGEVLLFCI TAAMYMFFFR CKDGLKGFTF
     SALRFIVGKE EIPTHSYSPE AAYAKVEQKT EKHEEKPRGM NIIALVRKLV DSVCKHGPRH
     RCCKHYEDNC ISYCIKGFIR MFSVGYLIQC CLRIPSAFRH LFTQPSRLLS LFYNKENFQL
     GAFLGSFVSI YKGTSCFLRW VRNLDDELHA IIAGFLAGVS MMFYKSTTIS MYLASKLVET
     MYFKGIEAGK VPYFPHADTI IYSISTAICF QAAVMEVQTL RPSYWKFLLR LTKGRFAVMN
     RKVLDVFGTG ASKNFPDFTP RLDPRYTTVT PELPIEFS