ID   TM135_CAEEL             Reviewed;         445 AA.
AC   Q95QD1;
DT   15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Transmembrane protein 135 homolog {ECO:0000305};
GN   Name=tmem-135 {ECO:0000312|WormBase:K02G10.3};
GN   ORFNames=K02G10.3 {ECO:0000312|WormBase:K02G10.3};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=21151927; DOI=10.1371/journal.pone.0014228;
RA   Exil V.J., Silva Avila D., Benedetto A., Exil E.A., Adams M.R., Au C.,
RA   Aschner M.;
RT   "Stressed-induced TMEM135 protein is part of a conserved genetic network
RT   involved in fat storage and longevity regulation in Caenorhabditis
RT   elegans.";
RL   PLoS ONE 5:E14228-E14228(2010).
CC   -!- FUNCTION: Involved in fat storage. {ECO:0000305|PubMed:21151927}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000305|PubMed:21151927}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC       {ECO:0000269|PubMed:21151927}.
CC   -!- INDUCTION: Up-regulated following cold exposure and upon fasting.
CC       {ECO:0000269|PubMed:21151927}.
CC   -!- DISRUPTION PHENOTYPE: Decreased longevity, mutants living for a
CC       significantly shorter time than wild-type worms (PubMed:21151927).
CC       Reduction in fat stores and reduction in mitochondrial action potential
CC       (PubMed:21151927). {ECO:0000269|PubMed:21151927}.
CC   -!- SIMILARITY: Belongs to the TMEM135 family. {ECO:0000305}.
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DR   EMBL; BX284606; CCD68559.1; -; Genomic_DNA.
DR   PIR; T16085; T16085.
DR   RefSeq; NP_508800.2; NM_076399.6.
DR   AlphaFoldDB; Q95QD1; -.
DR   DIP; DIP-24705N; -.
DR   STRING; 6239.K02G10.3.2; -.
DR   EPD; Q95QD1; -.
DR   PaxDb; Q95QD1; -.
DR   PeptideAtlas; Q95QD1; -.
DR   EnsemblMetazoa; K02G10.3.1; K02G10.3.1; WBGene00019345.
DR   GeneID; 180740; -.
DR   KEGG; cel:CELE_K02G10.3; -.
DR   UCSC; K02G10.3.1; c. elegans.
DR   CTD; 180740; -.
DR   WormBase; K02G10.3; CE31029; WBGene00019345; tmem-135.
DR   eggNOG; KOG1398; Eukaryota.
DR   GeneTree; ENSGT00390000000303; -.
DR   HOGENOM; CLU_046474_0_0_1; -.
DR   InParanoid; Q95QD1; -.
DR   OMA; TDKCVNA; -.
DR   OrthoDB; 706534at2759; -.
DR   PhylomeDB; Q95QD1; -.
DR   PRO; PR:Q95QD1; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00019345; Expressed in larva and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005811; C:lipid droplet; IDA:MGI.
DR   GO; GO:0008340; P:determination of adult lifespan; IDA:MGI.
DR   GO; GO:0010628; P:positive regulation of gene expression; IDA:MGI.
DR   GO; GO:0010884; P:positive regulation of lipid storage; IDA:MGI.
DR   GO; GO:0010918; P:positive regulation of mitochondrial membrane potential; IDA:MGI.
DR   GO; GO:0009409; P:response to cold; IDA:MGI.
DR   GO; GO:0032094; P:response to food; IDA:MGI.
DR   InterPro; IPR026749; Tmem135.
DR   InterPro; IPR031926; TMEM135_N.
DR   PANTHER; PTHR12459; PTHR12459; 1.
DR   Pfam; PF15982; TMEM135_C_rich; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..445
FT                   /note="Transmembrane protein 135 homolog"
FT                   /id="PRO_0000439034"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   445 AA;  50466 MW;  1089191975AFF692 CRC64;
     MGALSKLAHS LGQPILTATC YETIHTWNPD CNGAFFDALP VGLIFSLKTY ASFYLITNVV
     SKRGRLDKIN WKKFGIDVCQ SSLFLVTNMC FFLILLCKFR KWLGFFTPIT MGLVSSILAS
     GIAILVEKKS RRPALALYLI NLASETYYRH LANHGYVTMH TYGECIPFGI GLMLFTWLQS
     IGRLPKSFNG FMNVALKSNV SENLINEKKI PDNFRLFLEK LRSDYKKTEL CNHPHSCVSH
     SVESFAKNMT FGLTASSVLT VIRNVRTIIK NPLNLITLLV SKENLKLPLF AGFLPFIFNA
     TRCSLNRVKY VPPVLNNVFS AGLASVAMAF YPTVSIAMYC LWKAIETVYF DLVDRGYLPK
     FKNGEVILYA ITTGYVLWNA VVEPRAIRRG YLNFLFGLVG GKISLFNRRL YDHFGFVSRD
     VYTKIPEFDP KYAMINPMLY MPLVE