ID   TM135_RAT               Reviewed;         458 AA.
AC   Q5U4F4;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Transmembrane protein 135;
DE   AltName: Full=Peroxisomal membrane protein 52 {ECO:0000250|UniProtKB:Q9CYV5};
DE            Short=PMP52 {ECO:0000250|UniProtKB:Q9CYV5};
GN   Name=Tmem135;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=17522052; DOI=10.1074/jbc.m610910200;
RA   Islinger M., Lueers G.H., Li K.W., Loos M., Voelkl A.;
RT   "Rat liver peroxisomes after fibrate treatment: a survey using quantitative
RT   mass spectrometry.";
RL   J. Biol. Chem. 282:23055-23069(2007).
CC   -!- FUNCTION: Involved in mitochondrial metabolism by regulating the
CC       balance between mitochondrial fusion and fission (By similarity). May
CC       act as a regulator of mitochondrial fission that promotes DNM1L-
CC       dependent fission through activation of DNM1L (By similarity). May be
CC       involved in peroxisome organization (PubMed:17522052).
CC       {ECO:0000250|UniProtKB:Q9CYV5, ECO:0000269|PubMed:17522052}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:Q9CYV5}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9CYV5}. Peroxisome membrane
CC       {ECO:0000305|PubMed:17522052}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM135 family. {ECO:0000305}.
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DR   EMBL; BC085115; AAH85115.1; -; mRNA.
DR   RefSeq; NP_001013918.1; NM_001013896.1.
DR   AlphaFoldDB; Q5U4F4; -.
DR   STRING; 10116.ENSRNOP00000022578; -.
DR   PaxDb; Q5U4F4; -.
DR   PRIDE; Q5U4F4; -.
DR   Ensembl; ENSRNOT00000022578; ENSRNOP00000022578; ENSRNOG00000016815.
DR   GeneID; 293098; -.
DR   KEGG; rno:293098; -.
DR   UCSC; RGD:1309948; rat.
DR   CTD; 65084; -.
DR   RGD; 1309948; Tmem135.
DR   eggNOG; KOG1398; Eukaryota.
DR   GeneTree; ENSGT00390000000303; -.
DR   HOGENOM; CLU_046474_0_0_1; -.
DR   InParanoid; Q5U4F4; -.
DR   OMA; TDKCVNA; -.
DR   OrthoDB; 706534at2759; -.
DR   PhylomeDB; Q5U4F4; -.
DR   TreeFam; TF314580; -.
DR   PRO; PR:Q5U4F4; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000016815; Expressed in liver and 18 other tissues.
DR   Genevisible; Q5U4F4; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005811; C:lipid droplet; ISO:RGD.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005777; C:peroxisome; IDA:UniProtKB.
DR   GO; GO:0007031; P:peroxisome organization; IDA:UniProtKB.
DR   GO; GO:0090140; P:regulation of mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:0009409; P:response to cold; ISO:RGD.
DR   GO; GO:0032094; P:response to food; ISO:RGD.
DR   InterPro; IPR026749; Tmem135.
DR   InterPro; IPR031926; TMEM135_N.
DR   PANTHER; PTHR12459; PTHR12459; 1.
DR   Pfam; PF15982; TMEM135_C_rich; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Peroxisome; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..458
FT                   /note="Transmembrane protein 135"
FT                   /id="PRO_0000284624"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   458 AA;  52359 MW;  C300904899D7C915 CRC64;
     MAALSKSIPH NCYEIGHTWN PSCRVSFLQI TWGALEESLR IYAPLYLIAA VLRKRKLEYY
     LYKLLPEILQ SASFLTANGA LYITFFCVLR KILGKFYSWT PGFGAALPAS YVAILIERKS
     RRGLLTIYMA NLATETLFRM GVARGTITTL RNGEVLLFCI TAAMYMFFFR CKDGLKGFTF
     SALRFIVGKE EIPTHSYSPE TAYAKVEQKR EKHRGTTRAM SLIALVRSLV DSICKHGPRH
     RCCKHYEDNC ISYCIKGFIR MFSVGYLIQC CLRIPSAFRH LFTEPSRLLS LFYNKENFQL
     GAFLGSFVSI YKGTSCFLRW IRNLDDELHA IVAGFLAGVS MMFYKSTTIS MYLASKLVET
     MYFKGIEAGK VPYFPQADTI IYSISTAICF HAAVMEVQNL RPSYWKFLLR LTKGRFALMN
     RKALDVFGTG ASREFHNFIP RLDPRYTVVT PELPIDFS