ID   TM135_XENLA             Reviewed;         453 AA.
AC   Q6GQ39;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Transmembrane protein 135;
DE   AltName: Full=Peroxisomal membrane protein 52;
DE            Short=PMP52;
GN   Name=tmem135;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in mitochondrial metabolism by regulating the
CC       balance between mitochondrial fusion and fission. May act as a
CC       regulator of mitochondrial fission that promotes DNM1L-dependent
CC       fission through activation of DNM1L. May be involved in peroxisome
CC       organization. {ECO:0000250|UniProtKB:Q5U4F4,
CC       ECO:0000250|UniProtKB:Q9CYV5}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:Q9CYV5}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9CYV5}. Peroxisome membrane
CC       {ECO:0000250|UniProtKB:Q9CYV5}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM135 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC072909; AAH72909.1; -; mRNA.
DR   RefSeq; NP_001085541.1; NM_001092072.1.
DR   AlphaFoldDB; Q6GQ39; -.
DR   TCDB; 1.B.69.2.5; the peroxysomal membrane porin 4 (pxmp4) family.
DR   DNASU; 443967; -.
DR   GeneID; 443967; -.
DR   KEGG; xla:443967; -.
DR   CTD; 443967; -.
DR   Xenbase; XB-GENE-6540651; tmem135.L.
DR   OrthoDB; 706534at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 443967; Expressed in intestine and 20 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0090140; P:regulation of mitochondrial fission; ISS:UniProtKB.
DR   InterPro; IPR026749; Tmem135.
DR   InterPro; IPR031926; TMEM135_N.
DR   PANTHER; PTHR12459; PTHR12459; 1.
DR   Pfam; PF15982; TMEM135_C_rich; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Peroxisome; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..453
FT                   /note="Transmembrane protein 135"
FT                   /id="PRO_0000284625"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   453 AA;  51956 MW;  5031B3EF8BCACEB4 CRC64;
     MAALSKSIPH SCYEIGHTWN PSCFGSYLQI TQGAMEESFK IYAPLYLVAA ILRRKNLDYY
     VHKLLPELLQ STSFLTANGS LYIAFFCILR KLLGRFYFWT PGFGAALPAS YAAILIERKS
     RRGLLTIYMA NQATEALFRM GVTRGYIKPI RHGEVLLFCI TSALYMFFFR CRDGLKGFAF
     SALKFIVGKE EIPAHALLPE NMYVKAEQKS KEHRGLSRNS LKRLMDIICK HGPRHRCCKH
     YEDNCISYCI KGFIRMFSIG YLIQCCLRIP STFRHLFTKP SRLLSLFYNK ENFQLGAFLG
     SFVSIYKGTS CFLRWVRNLD DELHALVAGF LAGISMMFYK STTISMYLAS KLVETMYFKG
     IEAGKCPYFP HADSVIYAVS TAVCFHAAVM EVQNLRPSYW KFLQRLTKGR FALMNRKALD
     VFDSEASKNF NNFVPKLDPR FCIVKPELPL DFS