ID   TM138_BOVIN             Reviewed;         162 AA.
AC   A5PJY4;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Transmembrane protein 138;
GN   Name=TMEM138;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal medulla, and Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ciliogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
CC       Note=Localizes to vesicles en route to the base of cilium.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM138 family. {ECO:0000305}.
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DR   EMBL; DAAA02063463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC142285; AAI42286.1; -; mRNA.
DR   EMBL; BC142428; AAI42429.1; -; mRNA.
DR   RefSeq; NP_001092437.1; NM_001098967.1.
DR   AlphaFoldDB; A5PJY4; -.
DR   STRING; 9913.ENSBTAP00000028789; -.
DR   PaxDb; A5PJY4; -.
DR   Ensembl; ENSBTAT00000028789; ENSBTAP00000028789; ENSBTAG00000021604.
DR   GeneID; 514277; -.
DR   KEGG; bta:514277; -.
DR   CTD; 51524; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021604; -.
DR   VGNC; VGNC:35971; TMEM138.
DR   eggNOG; ENOG502RWE6; Eukaryota.
DR   GeneTree; ENSGT00390000018587; -.
DR   HOGENOM; CLU_104681_0_0_1; -.
DR   InParanoid; A5PJY4; -.
DR   OMA; RYTYLLM; -.
DR   OrthoDB; 1480637at2759; -.
DR   TreeFam; TF315159; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000021604; Expressed in retina and 102 other tissues.
DR   ExpressionAtlas; A5PJY4; baseline and differential.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR024133; TM_138.
DR   PANTHER; PTHR13306; PTHR13306; 1.
DR   Pfam; PF14935; TMEM138; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Glycoprotein;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix; Vacuole.
FT   CHAIN           1..162
FT                   /note="Transmembrane protein 138"
FT                   /id="PRO_0000416294"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   162 AA;  19271 MW;  CE6388AEA55069E9 CRC64;
     MLQTSNYSLV LSLQFLLLSY DLFVNSFSEL LRMAPVIQLV LFIIQDIAIL FNIIIIFLMF
     FNTFVFQAGL VNLLFHKFKG TIILTAVYFA LSISLHVWVM NLRWKNSNCF VWTDGLQTLF
     VFQRLAAVLY CYFYKRTAVR LGDPRFYQDS LWLRMEFMQV RR