TM138_DANRE
ID TM138_DANRE Reviewed; 162 AA.
AC E7FDE0;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 1.
DT 03-AUG-2022, entry version 52.
DE RecName: Full=Transmembrane protein 138;
GN Name=tmem138;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP DISRUPTION PHENOTYPE.
RX PubMed=22282472; DOI=10.1126/science.1213506;
RA Lee J.H., Silhavy J.L., Lee J.E., Al-Gazali L., Thomas S., Davis E.E.,
RA Bielas S.L., Hill K.J., Iannicelli M., Brancati F., Gabriel S.B., Russ C.,
RA Logan C.V., Sharif S.M., Bennett C.P., Abe M., Hildebrandt F., Diplas B.H.,
RA Attie-Bitach T., Katsanis N., Rajab A., Koul R., Sztriha L., Waters E.R.,
RA Ferro-Novick S., Woods G.C., Johnson C.A., Valente E.M., Zaki M.S.,
RA Gleeson J.G.;
RT "Evolutionarily assembled cis-regulatory module at a human ciliopathy
RT locus.";
RL Science 335:966-969(2012).
CC -!- FUNCTION: Required for ciliogenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
CC Note=Localizes to vesicles en route to the base of cilium.
CC {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Ciliary phenotypes such as pericardial effusion,
CC curved or kinked tail, as well as gastrulation defects.
CC {ECO:0000269|PubMed:22282472}.
CC -!- SIMILARITY: Belongs to the TMEM138 family. {ECO:0000305}.
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DR EMBL; CU855758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002666816.1; XM_002666770.4.
DR AlphaFoldDB; E7FDE0; -.
DR SMR; E7FDE0; -.
DR STRING; 7955.ENSDARP00000129379; -.
DR PaxDb; E7FDE0; -.
DR Ensembl; ENSDART00000156438; ENSDARP00000129379; ENSDARG00000090543.
DR GeneID; 100332440; -.
DR KEGG; dre:100332440; -.
DR CTD; 51524; -.
DR ZFIN; ZDB-GENE-120912-1; tmem138.
DR eggNOG; ENOG502RWE6; Eukaryota.
DR GeneTree; ENSGT00390000018587; -.
DR HOGENOM; CLU_104681_0_0_1; -.
DR InParanoid; E7FDE0; -.
DR OMA; RYTYLLM; -.
DR OrthoDB; 1480637at2759; -.
DR PhylomeDB; E7FDE0; -.
DR TreeFam; TF315159; -.
DR PRO; PR:E7FDE0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 25.
DR Bgee; ENSDARG00000090543; Expressed in mature ovarian follicle and 21 other tissues.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR InterPro; IPR024133; TM_138.
DR PANTHER; PTHR13306; PTHR13306; 1.
DR Pfam; PF14935; TMEM138; 1.
PE 3: Inferred from homology;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Glycoprotein;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix; Vacuole.
FT CHAIN 1..162
FT /note="Transmembrane protein 138"
FT /id="PRO_0000416296"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 162 AA; 19234 MW; 17E8E25A634BEC7E CRC64;
MLQTNNYSLV LLIQLALLTF DLFVNSFSEL LRSAPVIQLV LFIIQDIGIL FNVIIILLMM
FNTYVFQVGL VSLLLERFRA MLILSALYLT LSICFHCWVM NLRWMESNRF VWTDGLQVLF
VFQRIAAVLY YYFYKRTTEY LGDPRLYEDS PWLRDAFARA RQ
