TM138_MOUSE
ID TM138_MOUSE Reviewed; 162 AA.
AC Q9D6G5; Q9D9A8;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Transmembrane protein 138;
GN Name=Tmem138;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Hippocampus, Pancreas, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Required for ciliogenesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
CC Note=Localizes to vesicles en route to the base of cilium.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D6G5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D6G5-2; Sequence=VSP_024893, VSP_024894;
CC -!- SIMILARITY: Belongs to the TMEM138 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK007197; BAB24895.1; -; mRNA.
DR EMBL; AK013694; BAB28958.1; -; mRNA.
DR EMBL; AK050471; BAC34274.1; -; mRNA.
DR EMBL; BC058237; AAH58237.1; -; mRNA.
DR EMBL; BC107026; AAI07027.1; -; mRNA.
DR EMBL; BC132574; AAI32575.1; -; mRNA.
DR EMBL; BC132578; AAI32579.1; -; mRNA.
DR CCDS; CCDS29581.1; -. [Q9D6G5-1]
DR RefSeq; NP_001289147.1; NM_001302218.1. [Q9D6G5-2]
DR RefSeq; NP_082687.1; NM_028411.4. [Q9D6G5-1]
DR RefSeq; XP_011245668.1; XM_011247366.1. [Q9D6G5-1]
DR RefSeq; XP_011245669.1; XM_011247367.1. [Q9D6G5-1]
DR AlphaFoldDB; Q9D6G5; -.
DR STRING; 10090.ENSMUSP00000025568; -.
DR GlyGen; Q9D6G5; 1 site.
DR PhosphoSitePlus; Q9D6G5; -.
DR PaxDb; Q9D6G5; -.
DR PRIDE; Q9D6G5; -.
DR ProteomicsDB; 259527; -. [Q9D6G5-1]
DR Antibodypedia; 28203; 30 antibodies from 14 providers.
DR Ensembl; ENSMUST00000025568; ENSMUSP00000025568; ENSMUSG00000024666. [Q9D6G5-1]
DR Ensembl; ENSMUST00000236099; ENSMUSP00000157715; ENSMUSG00000024666. [Q9D6G5-1]
DR GeneID; 72982; -.
DR KEGG; mmu:72982; -.
DR UCSC; uc008gqd.2; mouse. [Q9D6G5-1]
DR UCSC; uc008gqf.2; mouse. [Q9D6G5-2]
DR CTD; 51524; -.
DR MGI; MGI:1920232; Tmem138.
DR VEuPathDB; HostDB:ENSMUSG00000024666; -.
DR eggNOG; ENOG502RWE6; Eukaryota.
DR GeneTree; ENSGT00390000018587; -.
DR HOGENOM; CLU_104681_0_0_1; -.
DR InParanoid; Q9D6G5; -.
DR OMA; RYTYLLM; -.
DR OrthoDB; 1480637at2759; -.
DR PhylomeDB; Q9D6G5; -.
DR TreeFam; TF315159; -.
DR BioGRID-ORCS; 72982; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Tmem138; mouse.
DR PRO; PR:Q9D6G5; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9D6G5; protein.
DR Bgee; ENSMUSG00000024666; Expressed in retinal neural layer and 136 other tissues.
DR ExpressionAtlas; Q9D6G5; baseline and differential.
DR Genevisible; Q9D6G5; MM.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR InterPro; IPR024133; TM_138.
DR PANTHER; PTHR13306; PTHR13306; 1.
DR Pfam; PF14935; TMEM138; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cilium;
KW Cilium biogenesis/degradation; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Vacuole.
FT CHAIN 1..162
FT /note="Transmembrane protein 138"
FT /id="PRO_0000285701"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 101
FT /note="N -> I (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024893"
FT VAR_SEQ 102..162
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024894"
SQ SEQUENCE 162 AA; 19150 MW; 4E1D72AD014E29E0 CRC64;
MLQTGNYSLV LSLQFLLLSY DLFVNSFSEL LRMAPVIQLV LFIIQDIAIL FNIIIIFLMF
FNTFVFQAGL VNLLFHKFKG TIILTSVYLA LSISLHVWVM NVRWKNSSSF SWTNGLQTLF
VFQRLAAVLY CYFYKRTAVR LGDPRFYQDS LWLRKEFMQV RR
