ID   TM138_XENTR             Reviewed;         162 AA.
AC   Q66JC0;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Transmembrane protein 138;
GN   Name=tmem138; ORFNames=TGas052n20.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ciliogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
CC       Note=Localizes to vesicles en route to the base of cilium.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM138 family. {ECO:0000305}.
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DR   EMBL; CR761875; CAJ83601.1; -; mRNA.
DR   EMBL; BC080981; AAH80981.1; -; mRNA.
DR   RefSeq; NP_001008082.1; NM_001008081.1.
DR   AlphaFoldDB; Q66JC0; -.
DR   STRING; 8364.ENSXETP00000019393; -.
DR   PaxDb; Q66JC0; -.
DR   DNASU; 493444; -.
DR   Ensembl; ENSXETT00000019393; ENSXETP00000019393; ENSXETG00000008824.
DR   GeneID; 493444; -.
DR   KEGG; xtr:493444; -.
DR   CTD; 51524; -.
DR   Xenbase; XB-GENE-973706; tmem138.
DR   eggNOG; ENOG502RWE6; Eukaryota.
DR   HOGENOM; CLU_104681_0_0_1; -.
DR   InParanoid; Q66JC0; -.
DR   OMA; RFRTMLM; -.
DR   OrthoDB; 1480637at2759; -.
DR   PhylomeDB; Q66JC0; -.
DR   TreeFam; TF315159; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000008824; Expressed in 2-cell stage embryo and 13 other tissues.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR024133; TM_138.
DR   PANTHER; PTHR13306; PTHR13306; 1.
DR   Pfam; PF14935; TMEM138; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Glycoprotein;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix; Vacuole.
FT   CHAIN           1..162
FT                   /note="Transmembrane protein 138"
FT                   /id="PRO_0000285702"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   162 AA;  18864 MW;  0948F7095154382C CRC64;
     MLQPGNYSLV LSLQFLLLLF DLFVNSFSEL LRDPPVNQLV LFILQDVGIL FAAIVLFLML
     FNTFVFQAGL VSLLCQRFQV TVILCAVYIA LSISLHVWLM NLRWTGANRF VWSDGLLALF
     VLQRFVAVLY FYYYKRTALS MGDSRFYHDS LWLRKEFARV RG