TM139_HUMAN
ID TM139_HUMAN Reviewed; 216 AA.
AC Q8IV31; B2RCL5; D3DXD4; Q6ZME2; Q8NC22; Q96AU8;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Transmembrane protein 139;
DE Flags: Precursor;
GN Name=TMEM139; ORFNames=UNQ1932/PRO4407;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hepatoma, and Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP FUNCTION, AND INTERACTION WITH SLC4A1.
RX PubMed=26049106; DOI=10.1016/j.bbrc.2015.05.128;
RA Nuiplot N.O., Junking M., Duangtum N., Khunchai S., Sawasdee N.,
RA Yenchitsomanus P.T., Akkarapatumwong V.;
RT "Transmembrane protein 139 (TMEM139) interacts with human kidney isoform of
RT anion exchanger 1 (kAE1).";
RL Biochem. Biophys. Res. Commun. 463:706-711(2015).
CC -!- FUNCTION: May be involved in cellular trafficking of proteins such as
CC SLC4A1. {ECO:0000305|PubMed:26049106}.
CC -!- SUBUNIT: Interacts with isoform 2 of SLC4A1 (PubMed:26049106).
CC {ECO:0000269|PubMed:26049106}.
CC -!- INTERACTION:
CC Q8IV31; O95870: ABHD16A; NbExp=3; IntAct=EBI-7238458, EBI-348517;
CC Q8IV31; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-7238458, EBI-11522760;
CC Q8IV31; Q9BQE5: APOL2; NbExp=3; IntAct=EBI-7238458, EBI-4290634;
CC Q8IV31; P27449: ATP6V0C; NbExp=3; IntAct=EBI-7238458, EBI-721179;
CC Q8IV31; Q92843: BCL2L2; NbExp=3; IntAct=EBI-7238458, EBI-707714;
CC Q8IV31; P48509: CD151; NbExp=3; IntAct=EBI-7238458, EBI-10210332;
CC Q8IV31; O95674: CDS2; NbExp=3; IntAct=EBI-7238458, EBI-3913685;
CC Q8IV31; Q9NWW5: CLN6; NbExp=3; IntAct=EBI-7238458, EBI-6165897;
CC Q8IV31; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-7238458, EBI-11522780;
CC Q8IV31; O43169: CYB5B; NbExp=3; IntAct=EBI-7238458, EBI-1058710;
CC Q8IV31; Q96IV6: FAXDC2; NbExp=3; IntAct=EBI-7238458, EBI-12142299;
CC Q8IV31; O00180: KCNK1; NbExp=3; IntAct=EBI-7238458, EBI-3914675;
CC Q8IV31; Q13021: MALL; NbExp=3; IntAct=EBI-7238458, EBI-750078;
CC Q8IV31; Q9NX47: MARCHF5; NbExp=3; IntAct=EBI-7238458, EBI-2341610;
CC Q8IV31; P30301: MIP; NbExp=3; IntAct=EBI-7238458, EBI-8449636;
CC Q8IV31; Q9H115: NAPB; NbExp=3; IntAct=EBI-7238458, EBI-3921185;
CC Q8IV31; P46934: NEDD4; NbExp=2; IntAct=EBI-7238458, EBI-726944;
CC Q8IV31; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-7238458, EBI-10317425;
CC Q8IV31; Q16617: NKG7; NbExp=3; IntAct=EBI-7238458, EBI-3919611;
CC Q8IV31; P42857: NSG1; NbExp=3; IntAct=EBI-7238458, EBI-6380741;
CC Q8IV31; Q5VZY2: PLPP4; NbExp=3; IntAct=EBI-7238458, EBI-10485931;
CC Q8IV31; Q01453: PMP22; NbExp=3; IntAct=EBI-7238458, EBI-2845982;
CC Q8IV31; Q59EV6: PPGB; NbExp=3; IntAct=EBI-7238458, EBI-14210385;
CC Q8IV31; O75396: SEC22B; NbExp=3; IntAct=EBI-7238458, EBI-1058865;
CC Q8IV31; P11686: SFTPC; NbExp=3; IntAct=EBI-7238458, EBI-10197617;
CC Q8IV31; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-7238458, EBI-10262251;
CC Q8IV31; P78382: SLC35A1; NbExp=3; IntAct=EBI-7238458, EBI-12870360;
CC Q8IV31; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-7238458, EBI-8640191;
CC Q8IV31; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-7238458, EBI-12845616;
CC Q8IV31; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-7238458, EBI-10171534;
CC Q8IV31; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-7238458, EBI-741829;
CC Q8IV31; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-7238458, EBI-2852148;
CC Q8IV31; Q9Y228: TRAF3IP3; NbExp=3; IntAct=EBI-7238458, EBI-765817;
CC Q8IV31; Q9Y5Z9: UBIAD1; NbExp=3; IntAct=EBI-7238458, EBI-2819725;
CC Q8IV31; O75841: UPK1B; NbExp=3; IntAct=EBI-7238458, EBI-12237619;
CC Q8IV31; O95183: VAMP5; NbExp=3; IntAct=EBI-7238458, EBI-10191195;
CC Q8IV31; P46937: YAP1; NbExp=2; IntAct=EBI-7238458, EBI-1044059;
CC Q8IV31; O95070: YIF1A; NbExp=3; IntAct=EBI-7238458, EBI-2799703;
CC Q8IV31; O95159: ZFPL1; NbExp=3; IntAct=EBI-7238458, EBI-718439;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH16719.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY358781; AAQ89141.1; -; mRNA.
DR EMBL; AK172816; BAD18786.1; -; mRNA.
DR EMBL; AK075067; BAC11382.1; -; mRNA.
DR EMBL; AK315170; BAG37612.1; -; mRNA.
DR EMBL; CH236959; EAL23784.1; -; Genomic_DNA.
DR EMBL; CH471198; EAW51871.1; -; Genomic_DNA.
DR EMBL; CH471198; EAW51873.1; -; Genomic_DNA.
DR EMBL; CH471198; EAW51875.1; -; Genomic_DNA.
DR EMBL; BC016719; AAH16719.1; ALT_INIT; mRNA.
DR EMBL; BC035517; AAH35517.1; -; mRNA.
DR CCDS; CCDS5878.1; -.
DR RefSeq; NP_001229702.1; NM_001242773.2.
DR RefSeq; NP_001229703.1; NM_001242774.2.
DR RefSeq; NP_001229704.1; NM_001242775.2.
DR RefSeq; NP_001269805.1; NM_001282876.1.
DR RefSeq; NP_001269806.1; NM_001282877.1.
DR RefSeq; NP_699176.1; NM_153345.3.
DR AlphaFoldDB; Q8IV31; -.
DR BioGRID; 126439; 46.
DR IntAct; Q8IV31; 43.
DR MINT; Q8IV31; -.
DR STRING; 9606.ENSP00000352284; -.
DR TCDB; 8.A.60.1.1; the transmembrane protein 139 (tmem139) family.
DR iPTMnet; Q8IV31; -.
DR PhosphoSitePlus; Q8IV31; -.
DR BioMuta; TMEM139; -.
DR DMDM; 74728027; -.
DR jPOST; Q8IV31; -.
DR MassIVE; Q8IV31; -.
DR PaxDb; Q8IV31; -.
DR PeptideAtlas; Q8IV31; -.
DR PRIDE; Q8IV31; -.
DR ProteomicsDB; 70645; -.
DR Antibodypedia; 46282; 63 antibodies from 17 providers.
DR DNASU; 135932; -.
DR Ensembl; ENST00000359333.8; ENSP00000352284.3; ENSG00000178826.11.
DR Ensembl; ENST00000409102.5; ENSP00000386879.1; ENSG00000178826.11.
DR Ensembl; ENST00000409244.5; ENSP00000386335.1; ENSG00000178826.11.
DR Ensembl; ENST00000409541.5; ENSP00000387044.1; ENSG00000178826.11.
DR Ensembl; ENST00000410004.1; ENSP00000386564.1; ENSG00000178826.11.
DR GeneID; 135932; -.
DR KEGG; hsa:135932; -.
DR MANE-Select; ENST00000359333.8; ENSP00000352284.3; NM_001282876.2; NP_001269805.1.
DR UCSC; uc003wck.6; human.
DR CTD; 135932; -.
DR DisGeNET; 135932; -.
DR GeneCards; TMEM139; -.
DR HGNC; HGNC:22058; TMEM139.
DR HPA; ENSG00000178826; Tissue enhanced (intestine, kidney).
DR MIM; 616524; gene.
DR neXtProt; NX_Q8IV31; -.
DR OpenTargets; ENSG00000178826; -.
DR PharmGKB; PA144596260; -.
DR VEuPathDB; HostDB:ENSG00000178826; -.
DR eggNOG; ENOG502S6ZG; Eukaryota.
DR GeneTree; ENSGT00390000002723; -.
DR HOGENOM; CLU_121737_0_0_1; -.
DR InParanoid; Q8IV31; -.
DR OMA; FYEDNWT; -.
DR OrthoDB; 1391311at2759; -.
DR PhylomeDB; Q8IV31; -.
DR TreeFam; TF338466; -.
DR PathwayCommons; Q8IV31; -.
DR SignaLink; Q8IV31; -.
DR BioGRID-ORCS; 135932; 9 hits in 1069 CRISPR screens.
DR GenomeRNAi; 135932; -.
DR Pharos; Q8IV31; Tdark.
DR PRO; PR:Q8IV31; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8IV31; protein.
DR Bgee; ENSG00000178826; Expressed in ileal mucosa and 131 other tissues.
DR Genevisible; Q8IV31; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR038805; TMEM139.
DR PANTHER; PTHR36294; PTHR36294; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..216
FT /note="Transmembrane protein 139"
FT /id="PRO_0000285948"
FT TOPO_DOM 26..34
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..216
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 104..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 146
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 155
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT CONFLICT 203
FT /note="D -> G (in Ref. 2; BAD18786)"
FT /evidence="ECO:0000305"
FT CONFLICT 209
FT /note="Y -> C (in Ref. 3; BAC11382)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 216 AA; 23729 MW; DF5A7DB1E4126063 CRC64;
MVPMHLLGRL EKPLLLLCCA SFLLGLALLG IKTDITPVAY FFLTLGGFFL FAYLLVRFLE
WGLRSQLQSM QTESPGPSGN ARDNEAFEVP VYEEAVVGLE SQCRPQELDQ PPPYSTVVIP
PAPEEEQPSH PEGSRRAKLE QRRMASEGSM AQEGSPGRAP INLRLRGPRA VSTAPDLQSL
AAVPTLEPLT PPPAYDVCFG HPDDDSVFYE DNWAPP
