TM140_HUMAN
ID TM140_HUMAN Reviewed; 185 AA.
AC Q9NV12; A4D1P9; Q8WUC3;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Transmembrane protein 140;
GN Name=TMEM140;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-29.
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LEU-29.
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLN-7; GLU-11 AND
RP LEU-29.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] GLU-112.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- INTERACTION:
CC Q9NV12; Q96BI3: APH1A; NbExp=3; IntAct=EBI-2844246, EBI-2606935;
CC Q9NV12; Q13520: AQP6; NbExp=3; IntAct=EBI-2844246, EBI-13059134;
CC Q9NV12; P07307-3: ASGR2; NbExp=3; IntAct=EBI-2844246, EBI-12808270;
CC Q9NV12; P20273-5: CD22; NbExp=3; IntAct=EBI-2844246, EBI-13320645;
CC Q9NV12; P19397: CD53; NbExp=3; IntAct=EBI-2844246, EBI-6657396;
CC Q9NV12; P11912: CD79A; NbExp=3; IntAct=EBI-2844246, EBI-7797864;
CC Q9NV12; Q99675: CGRRF1; NbExp=3; IntAct=EBI-2844246, EBI-2130213;
CC Q9NV12; O00501: CLDN5; NbExp=3; IntAct=EBI-2844246, EBI-18400628;
CC Q9NV12; O95471: CLDN7; NbExp=3; IntAct=EBI-2844246, EBI-740744;
CC Q9NV12; Q6ZS10: CLEC17A; NbExp=3; IntAct=EBI-2844246, EBI-11977093;
CC Q9NV12; P58418: CLRN1; NbExp=3; IntAct=EBI-2844246, EBI-17274839;
CC Q9NV12; Q15125: EBP; NbExp=3; IntAct=EBI-2844246, EBI-3915253;
CC Q9NV12; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-2844246, EBI-18304435;
CC Q9NV12; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-2844246, EBI-18938272;
CC Q9NV12; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-2844246, EBI-12142257;
CC Q9NV12; Q8NBJ4: GOLM1; NbExp=3; IntAct=EBI-2844246, EBI-712073;
CC Q9NV12; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-2844246, EBI-13345167;
CC Q9NV12; O15529: GPR42; NbExp=3; IntAct=EBI-2844246, EBI-18076404;
CC Q9NV12; Q9UM44: HHLA2; NbExp=3; IntAct=EBI-2844246, EBI-2867874;
CC Q9NV12; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-2844246, EBI-18053395;
CC Q9NV12; P38484: IFNGR2; NbExp=3; IntAct=EBI-2844246, EBI-3905457;
CC Q9NV12; Q15842: KCNJ8; NbExp=3; IntAct=EBI-2844246, EBI-17440235;
CC Q9NV12; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-2844246, EBI-10171774;
CC Q9NV12; Q16553: LY6E; NbExp=3; IntAct=EBI-2844246, EBI-18234679;
CC Q9NV12; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-2844246, EBI-11956541;
CC Q9NV12; O14880: MGST3; NbExp=3; IntAct=EBI-2844246, EBI-724754;
CC Q9NV12; Q7Z6M3: MILR1; NbExp=3; IntAct=EBI-2844246, EBI-18391669;
CC Q9NV12; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-2844246, EBI-12806656;
CC Q9NV12; Q15800: MSMO1; NbExp=3; IntAct=EBI-2844246, EBI-949102;
CC Q9NV12; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-2844246, EBI-716063;
CC Q9NV12; Q96TC7: RMDN3; NbExp=3; IntAct=EBI-2844246, EBI-1056589;
CC Q9NV12; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-2844246, EBI-17247926;
CC Q9NV12; Q3SXP7: SHISAL1; NbExp=3; IntAct=EBI-2844246, EBI-18037857;
CC Q9NV12; Q9Y3P8: SIT1; NbExp=3; IntAct=EBI-2844246, EBI-6977215;
CC Q9NV12; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-2844246, EBI-2823239;
CC Q9NV12; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-2844246, EBI-17498703;
CC Q9NV12; P27105: STOM; NbExp=3; IntAct=EBI-2844246, EBI-1211440;
CC Q9NV12; Q8N205: SYNE4; NbExp=3; IntAct=EBI-2844246, EBI-7131783;
CC Q9NV12; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-2844246, EBI-19027521;
CC Q9NV12; Q6ZP80: TMEM182; NbExp=3; IntAct=EBI-2844246, EBI-10255122;
CC Q9NV12; Q6UW68: TMEM205; NbExp=3; IntAct=EBI-2844246, EBI-6269551;
CC Q9NV12; Q6UWW9: TMEM207; NbExp=3; IntAct=EBI-2844246, EBI-13301303;
CC Q9NV12; Q9P0T7: TMEM9; NbExp=3; IntAct=EBI-2844246, EBI-723976;
CC Q9NV12; Q9Y320: TMX2; NbExp=3; IntAct=EBI-2844246, EBI-6447886;
CC Q9NV12; O95859: TSPAN12; NbExp=3; IntAct=EBI-2844246, EBI-2466403;
CC Q9NV12; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-2844246, EBI-12195249;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK001862; BAA91948.1; -; mRNA.
DR EMBL; AC083862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236950; EAL24065.1; -; Genomic_DNA.
DR EMBL; BC020942; AAH20942.1; -; mRNA.
DR CCDS; CCDS5837.1; -.
DR RefSeq; NP_060765.4; NM_018295.4.
DR AlphaFoldDB; Q9NV12; -.
DR BioGRID; 120569; 57.
DR IntAct; Q9NV12; 49.
DR MINT; Q9NV12; -.
DR STRING; 9606.ENSP00000275767; -.
DR GlyGen; Q9NV12; 1 site.
DR iPTMnet; Q9NV12; -.
DR PhosphoSitePlus; Q9NV12; -.
DR BioMuta; TMEM140; -.
DR DMDM; 296452934; -.
DR PaxDb; Q9NV12; -.
DR PeptideAtlas; Q9NV12; -.
DR PRIDE; Q9NV12; -.
DR Antibodypedia; 18112; 31 antibodies from 7 providers.
DR DNASU; 55281; -.
DR Ensembl; ENST00000275767.3; ENSP00000275767.2; ENSG00000146859.6.
DR GeneID; 55281; -.
DR KEGG; hsa:55281; -.
DR MANE-Select; ENST00000275767.3; ENSP00000275767.2; NM_018295.5; NP_060765.4.
DR UCSC; uc003vsi.4; human.
DR CTD; 55281; -.
DR DisGeNET; 55281; -.
DR GeneCards; TMEM140; -.
DR HGNC; HGNC:21870; TMEM140.
DR HPA; ENSG00000146859; Tissue enhanced (skeletal).
DR neXtProt; NX_Q9NV12; -.
DR OpenTargets; ENSG00000146859; -.
DR PharmGKB; PA144596261; -.
DR VEuPathDB; HostDB:ENSG00000146859; -.
DR eggNOG; ENOG502S6FP; Eukaryota.
DR GeneTree; ENSGT00390000014089; -.
DR HOGENOM; CLU_125527_0_0_1; -.
DR InParanoid; Q9NV12; -.
DR OMA; NFCLWNQ; -.
DR OrthoDB; 1420340at2759; -.
DR PhylomeDB; Q9NV12; -.
DR TreeFam; TF336296; -.
DR PathwayCommons; Q9NV12; -.
DR SignaLink; Q9NV12; -.
DR BioGRID-ORCS; 55281; 12 hits in 1081 CRISPR screens.
DR ChiTaRS; TMEM140; human.
DR GenomeRNAi; 55281; -.
DR Pharos; Q9NV12; Tdark.
DR PRO; PR:Q9NV12; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9NV12; protein.
DR Bgee; ENSG00000146859; Expressed in blood and 158 other tissues.
DR Genevisible; Q9NV12; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028038; TM140.
DR PANTHER; PTHR16103; PTHR16103; 1.
DR Pfam; PF14985; TM140; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..185
FT /note="Transmembrane protein 140"
FT /id="PRO_0000274357"
FT TOPO_DOM 1..11
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..77
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..114
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..150
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..185
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 6
FT /note="P -> S (in dbSNP:rs292500)"
FT /id="VAR_030262"
FT VARIANT 7
FT /note="R -> Q (in dbSNP:rs3800592)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030263"
FT VARIANT 11
FT /note="Q -> E (in dbSNP:rs11558290)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030264"
FT VARIANT 29
FT /note="F -> L (in dbSNP:rs292501)"
FT /evidence="ECO:0000269|PubMed:12690205,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT /id="VAR_030265"
FT VARIANT 112
FT /note="A -> E (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs292502)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035670"
SQ SEQUENCE 185 AA; 20419 MW; 6BD0CE084FDBC53A CRC64;
MAGPRPRWRD QLLFMSIIVL VIVVICLMFY ALLWEAGNLT DLPNLRIGFY NFCLWNEDTS
TLQCHQFPEL EALGVPRVGL GLARLGVYGS LVLTLFAPQP LLLAQCNSDE RAWRLAVGFL
AVSSVLLAGG LGLFLSYVWK WVRLSLPGPG FLALGSAQAL LILLLIAMAV FPLRAERAES
KLESC
