TM140_MOUSE
ID TM140_MOUSE Reviewed; 185 AA.
AC Q8BGY5; Q8VDY2;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Transmembrane protein 140;
GN Name=Tmem140;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK030532; BAC27007.1; -; mRNA.
DR EMBL; BC020080; AAH20080.1; -; mRNA.
DR EMBL; BC023802; AAH23802.1; -; mRNA.
DR CCDS; CCDS19996.1; -.
DR RefSeq; NP_932103.1; NM_197986.2.
DR RefSeq; XP_006506603.1; XM_006506540.1.
DR RefSeq; XP_006506604.1; XM_006506541.2.
DR AlphaFoldDB; Q8BGY5; -.
DR STRING; 10090.ENSMUSP00000074482; -.
DR iPTMnet; Q8BGY5; -.
DR PhosphoSitePlus; Q8BGY5; -.
DR PaxDb; Q8BGY5; -.
DR PRIDE; Q8BGY5; -.
DR ProteomicsDB; 258902; -.
DR Antibodypedia; 18112; 31 antibodies from 7 providers.
DR DNASU; 68487; -.
DR Ensembl; ENSMUST00000074949; ENSMUSP00000074482; ENSMUSG00000057137.
DR GeneID; 68487; -.
DR KEGG; mmu:68487; -.
DR UCSC; uc009bhu.1; mouse.
DR CTD; 55281; -.
DR MGI; MGI:1915737; Tmem140.
DR VEuPathDB; HostDB:ENSMUSG00000057137; -.
DR eggNOG; ENOG502S6FP; Eukaryota.
DR GeneTree; ENSGT00390000014089; -.
DR HOGENOM; CLU_125527_0_0_1; -.
DR InParanoid; Q8BGY5; -.
DR OMA; TYTWKWI; -.
DR OrthoDB; 1420340at2759; -.
DR PhylomeDB; Q8BGY5; -.
DR TreeFam; TF336296; -.
DR BioGRID-ORCS; 68487; 2 hits in 38 CRISPR screens.
DR PRO; PR:Q8BGY5; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BGY5; protein.
DR Bgee; ENSMUSG00000057137; Expressed in hindlimb stylopod muscle and 138 other tissues.
DR ExpressionAtlas; Q8BGY5; baseline and differential.
DR Genevisible; Q8BGY5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028038; TM140.
DR PANTHER; PTHR16103; PTHR16103; 1.
DR Pfam; PF14985; TM140; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..185
FT /note="Transmembrane protein 140"
FT /id="PRO_0000274358"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..84
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..114
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..145
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..185
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 125
FT /note="I -> V (in Ref. 2; AAH20080)"
FT /evidence="ECO:0000305"
FT CONFLICT 136
FT /note="S -> F (in Ref. 2; AAH20080)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 185 AA; 20767 MW; 625120BB140A3F9B CRC64;
MAFSRLWRNN HLPFVGIMIL LAAALCLMFY ALLWKAGNLA DLPSLRIGFY NFCLWKEDMG
SLACYNFPEL DVLGIPQVGL ALARLGVYGA LVLTVFVPLP LLLAQYNRDE GEWRLAVCFL
AASSILLAGG LSLFLSFVWK WLRLSFLGPA LPALCLAQLL LIFLLVATVR FPPRDKEDKN
QWENC
