ID   TM141_DANRE             Reviewed;         124 AA.
AC   Q0D285;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Transmembrane protein 141;
GN   Name=tmem141; ORFNames=zgc:153677;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM141 family. {ECO:0000305}.
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DR   EMBL; BX276102; CAM46935.1; -; Genomic_DNA.
DR   EMBL; BC122376; AAI22377.1; -; mRNA.
DR   RefSeq; NP_001070066.1; NM_001076598.1.
DR   AlphaFoldDB; Q0D285; -.
DR   SMR; Q0D285; -.
DR   STRING; 7955.ENSDARP00000088257; -.
DR   PaxDb; Q0D285; -.
DR   Ensembl; ENSDART00000161252; ENSDARP00000133632; ENSDARG00000101963.
DR   GeneID; 767658; -.
DR   KEGG; dre:767658; -.
DR   CTD; 85014; -.
DR   ZFIN; ZDB-GENE-060929-272; tmem141.
DR   eggNOG; ENOG502SFAD; Eukaryota.
DR   GeneTree; ENSGT00940000153116; -.
DR   HOGENOM; CLU_163737_0_0_1; -.
DR   InParanoid; Q0D285; -.
DR   OMA; CQSNAFM; -.
DR   OrthoDB; 1464097at2759; -.
DR   PhylomeDB; Q0D285; -.
DR   TreeFam; TF330755; -.
DR   PRO; PR:Q0D285; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000101963; Expressed in muscle tissue and 21 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3350.20; -; 1.
DR   InterPro; IPR026788; Tmem141.
DR   InterPro; IPR038259; Tmem141_sf.
DR   PANTHER; PTHR47229; PTHR47229; 1.
DR   Pfam; PF15110; TMEM141; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..124
FT                   /note="Transmembrane protein 141"
FT                   /id="PRO_0000293710"
FT   TRANSMEM        29..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          97..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..124
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   124 AA;  13904 MW;  70E35F944AD14F46 CRC64;
     MVNIGLSKVD DAIVAKHPGL QQYVACQSYA FMKGTASFIL GTVGIFFGQR ALQKIIKYPL
     QWNLFVSIVS SSVFSYSVTR WETMKCSDVW LFLETGNIPD RNSDKEEPET SADSTTTQHE
     DVLE