TM141_HUMAN
ID TM141_HUMAN Reviewed; 108 AA.
AC Q96I45; A6NIZ7; Q5T5R5;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Transmembrane protein 141;
GN Name=TMEM141;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [5]
RP STRUCTURE BY NMR.
RX PubMed=22609626; DOI=10.1038/nmeth.2033;
RA Klammt C., Maslennikov I., Bayrhuber M., Eichmann C., Vajpai N., Chiu E.J.,
RA Blain K.Y., Esquivies L., Kwon J.H., Balana B., Pieper U., Sali A.,
RA Slesinger P.A., Kwiatkowski W., Riek R., Choe S.;
RT "Facile backbone structure determination of human membrane proteins by NMR
RT spectroscopy.";
RL Nat. Methods 9:834-839(2012).
CC -!- INTERACTION:
CC Q96I45; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-17681263, EBI-781551;
CC Q96I45; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-17681263, EBI-18304435;
CC Q96I45; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-17681263, EBI-1055254;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM141 family. {ECO:0000305}.
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DR EMBL; AL355987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471090; EAW88277.1; -; Genomic_DNA.
DR EMBL; BC007834; AAH07834.1; -; mRNA.
DR CCDS; CCDS7007.1; -.
DR RefSeq; NP_116317.1; NM_032928.3.
DR PDB; 2LOR; NMR; -; A=1-108.
DR PDBsum; 2LOR; -.
DR AlphaFoldDB; Q96I45; -.
DR BMRB; Q96I45; -.
DR SMR; Q96I45; -.
DR BioGRID; 124429; 9.
DR IntAct; Q96I45; 3.
DR STRING; 9606.ENSP00000290079; -.
DR BioMuta; TMEM141; -.
DR EPD; Q96I45; -.
DR jPOST; Q96I45; -.
DR MassIVE; Q96I45; -.
DR MaxQB; Q96I45; -.
DR PaxDb; Q96I45; -.
DR PeptideAtlas; Q96I45; -.
DR PRIDE; Q96I45; -.
DR ProteomicsDB; 76811; -.
DR Antibodypedia; 45420; 85 antibodies from 17 providers.
DR DNASU; 85014; -.
DR Ensembl; ENST00000290079.9; ENSP00000290079.8; ENSG00000244187.8.
DR GeneID; 85014; -.
DR KEGG; hsa:85014; -.
DR MANE-Select; ENST00000290079.9; ENSP00000290079.8; NM_032928.4; NP_116317.1.
DR UCSC; uc004cje.5; human.
DR CTD; 85014; -.
DR GeneCards; TMEM141; -.
DR HGNC; HGNC:28211; TMEM141.
DR HPA; ENSG00000244187; Low tissue specificity.
DR neXtProt; NX_Q96I45; -.
DR OpenTargets; ENSG00000244187; -.
DR PharmGKB; PA144596262; -.
DR VEuPathDB; HostDB:ENSG00000244187; -.
DR eggNOG; ENOG502SFAD; Eukaryota.
DR GeneTree; ENSGT00940000153116; -.
DR HOGENOM; CLU_163737_0_0_1; -.
DR InParanoid; Q96I45; -.
DR OMA; CQSNAFM; -.
DR OrthoDB; 1464097at2759; -.
DR PhylomeDB; Q96I45; -.
DR TreeFam; TF330755; -.
DR PathwayCommons; Q96I45; -.
DR SignaLink; Q96I45; -.
DR BioGRID-ORCS; 85014; 12 hits in 1078 CRISPR screens.
DR ChiTaRS; TMEM141; human.
DR GenomeRNAi; 85014; -.
DR Pharos; Q96I45; Tdark.
DR PRO; PR:Q96I45; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q96I45; protein.
DR Bgee; ENSG00000244187; Expressed in mucosa of transverse colon and 180 other tissues.
DR Genevisible; Q96I45; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3350.20; -; 1.
DR InterPro; IPR026788; Tmem141.
DR InterPro; IPR038259; Tmem141_sf.
DR PANTHER; PTHR47229; PTHR47229; 1.
DR Pfam; PF15110; TMEM141; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..108
FT /note="Transmembrane protein 141"
FT /id="PRO_0000279507"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT STRAND 3..5
FT /evidence="ECO:0007829|PDB:2LOR"
FT HELIX 6..16
FT /evidence="ECO:0007829|PDB:2LOR"
FT HELIX 20..39
FT /evidence="ECO:0007829|PDB:2LOR"
FT HELIX 40..43
FT /evidence="ECO:0007829|PDB:2LOR"
FT HELIX 44..53
FT /evidence="ECO:0007829|PDB:2LOR"
FT STRAND 56..60
FT /evidence="ECO:0007829|PDB:2LOR"
FT HELIX 62..95
FT /evidence="ECO:0007829|PDB:2LOR"
SQ SEQUENCE 108 AA; 11875 MW; 948494B8AC757657 CRC64;
MVNLGLSRVD DAVAAKHPGL GEYAACQSHA FMKGVFTFVT GTGMAFGLQM FIQRKFPYPL
QWSLLVAVVA GSVVSYGVTR VESEKCNNLW LFLETGQLPK DRSTDQRS
