ID   TM141_MOUSE             Reviewed;         108 AA.
AC   A2AJB2;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Transmembrane protein 141;
GN   Name=Tmem141; Synonyms=D2Ertd217e;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM141 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AK004380; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK004380; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AL732590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS50534.1; -.
DR   RefSeq; NP_001035219.2; NM_001040130.3.
DR   AlphaFoldDB; A2AJB2; -.
DR   SMR; A2AJB2; -.
DR   STRING; 10090.ENSMUSP00000121862; -.
DR   iPTMnet; A2AJB2; -.
DR   MaxQB; A2AJB2; -.
DR   PaxDb; A2AJB2; -.
DR   PeptideAtlas; A2AJB2; -.
DR   PRIDE; A2AJB2; -.
DR   ProteomicsDB; 259529; -.
DR   Antibodypedia; 45420; 85 antibodies from 17 providers.
DR   Ensembl; ENSMUST00000142087; ENSMUSP00000121862; ENSMUSG00000026939.
DR   GeneID; 51875; -.
DR   KEGG; mmu:51875; -.
DR   UCSC; uc008isx.2; mouse.
DR   CTD; 85014; -.
DR   MGI; MGI:1098773; Tmem141.
DR   VEuPathDB; HostDB:ENSMUSG00000026939; -.
DR   eggNOG; ENOG502SFAD; Eukaryota.
DR   GeneTree; ENSGT00940000153116; -.
DR   InParanoid; A2AJB2; -.
DR   OMA; CQSNAFM; -.
DR   OrthoDB; 1464097at2759; -.
DR   PhylomeDB; A2AJB2; -.
DR   TreeFam; TF330755; -.
DR   BioGRID-ORCS; 51875; 2 hits in 72 CRISPR screens.
DR   ChiTaRS; Tmem141; mouse.
DR   PRO; PR:A2AJB2; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; A2AJB2; protein.
DR   Bgee; ENSMUSG00000026939; Expressed in heart right ventricle and 246 other tissues.
DR   ExpressionAtlas; A2AJB2; baseline and differential.
DR   Genevisible; A2AJB2; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3350.20; -; 1.
DR   InterPro; IPR026788; Tmem141.
DR   InterPro; IPR038259; Tmem141_sf.
DR   PANTHER; PTHR47229; PTHR47229; 1.
DR   Pfam; PF15110; TMEM141; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..108
FT                   /note="Transmembrane protein 141"
FT                   /id="PRO_0000293709"
FT   TRANSMEM        30..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   108 AA;  11893 MW;  383B16E3DC1E7485 CRC64;
     MVNLGLSRVD DAVAARHPGL EEFAACQSHA FMKGVFTFVT GTGATFGLLM FIKRKFPYPV
     QWSFLVSAIA GSVASYRVTS MECQKCSNLW LFLETGQLPK DISTDPHD