ID   TM143_BOVIN             Reviewed;         457 AA.
AC   Q32PH2; A1L589;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Transmembrane protein 143;
GN   Name=TMEM143;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q32PH2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q32PH2-2; Sequence=VSP_024929;
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DR   EMBL; BT029876; ABM06128.1; -; mRNA.
DR   EMBL; BC108117; AAI08118.1; -; mRNA.
DR   RefSeq; NP_001032524.1; NM_001037447.2. [Q32PH2-1]
DR   RefSeq; XP_005219262.1; XM_005219205.2. [Q32PH2-2]
DR   AlphaFoldDB; Q32PH2; -.
DR   STRING; 9913.ENSBTAP00000009350; -.
DR   PaxDb; Q32PH2; -.
DR   PRIDE; Q32PH2; -.
DR   Ensembl; ENSBTAT00000009350; ENSBTAP00000009350; ENSBTAG00000007107. [Q32PH2-2]
DR   GeneID; 505862; -.
DR   KEGG; bta:505862; -.
DR   CTD; 55260; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007107; -.
DR   eggNOG; ENOG502QR4I; Eukaryota.
DR   GeneTree; ENSGT00940000154315; -.
DR   HOGENOM; CLU_043601_0_0_1; -.
DR   InParanoid; Q32PH2; -.
DR   OMA; ERFIPFR; -.
DR   OrthoDB; 1506124at2759; -.
DR   TreeFam; TF329116; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000007107; Expressed in corpus luteum and 104 other tissues.
DR   ExpressionAtlas; Q32PH2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   InterPro; IPR022227; DUF3754.
DR   Pfam; PF12576; DUF3754; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..457
FT                   /note="Transmembrane protein 143"
FT                   /id="PRO_0000285957"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          429..457
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         316
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8VD26"
FT   VAR_SEQ         372
FT                   /note="E -> EA (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16305752"
FT                   /id="VSP_024929"
FT   CONFLICT        252
FT                   /note="E -> K (in Ref. 1; ABM06128)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   457 AA;  51449 MW;  F706EE17D30D5036 CRC64;
     MLHVTRGVWG SIVRVWPLLP SFLGHSRALS SLEAKMGEYR KMWNPTEPRD WAQQYRERHI
     PFSKEQLLRL LIQEFHSTPA EKAALEEFTA HVDFCTLFHY HHVLTQLQAL YDPINPDRET
     LDQPSLTDPQ RLSNEKEVLQ ALEPLLAQAN FSPLTEDTLA YALVVHHPQD EVQVTINLDQ
     YIYMHFWALG QRVGKMPRKS SVGSKRFFFK SPPAERRYFK RVILAARTKK GHLVLKSFKD
     TPLEGLEQLL PELKVRTSTL QRAILNVTLI VSGVVFFVNV GMVVLSDLKM ATSLLLLLFA
     AFMGLRAAKM FGHRRSAQAL ELAHMLYYRS TSNNAELLSA LVLRAQDEHT KETLLAHSFL
     ARRPGGAKGP PEETSQWLQS EVENWLLAQS GCDVAFNGKR ALAHLQALPP TVGMYPPPGL
     PKLDLLATLS SPKSAPSDDN SLEKPLGPAQ PSHLVGN