TM143_MOUSE
ID TM143_MOUSE Reviewed; 458 AA.
AC Q8VD26; Q8BHU3; Q8BI00; Q8BI09;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Transmembrane protein 143;
GN Name=Tmem143;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Hypothalamus, and Oviduct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, and Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8VD26-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8VD26-2; Sequence=VSP_024934, VSP_024935;
CC Name=3;
CC IsoId=Q8VD26-3; Sequence=VSP_024933, VSP_024936, VSP_024937;
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DR EMBL; AK035836; BAC29207.1; -; mRNA.
DR EMBL; AK039173; BAC30266.1; -; mRNA.
DR EMBL; AK087636; BAC39951.1; -; mRNA.
DR EMBL; BC017618; AAH17618.1; -; mRNA.
DR CCDS; CCDS21269.1; -. [Q8VD26-1]
DR RefSeq; NP_659050.2; NM_144801.2.
DR AlphaFoldDB; Q8VD26; -.
DR STRING; 10090.ENSMUSP00000070405; -.
DR iPTMnet; Q8VD26; -.
DR PhosphoSitePlus; Q8VD26; -.
DR MaxQB; Q8VD26; -.
DR PaxDb; Q8VD26; -.
DR PeptideAtlas; Q8VD26; -.
DR PRIDE; Q8VD26; -.
DR ProteomicsDB; 259530; -. [Q8VD26-1]
DR ProteomicsDB; 259531; -. [Q8VD26-2]
DR ProteomicsDB; 259532; -. [Q8VD26-3]
DR GeneID; 70209; -.
DR KEGG; mmu:70209; -.
DR CTD; 55260; -.
DR MGI; MGI:1917459; Tmem143.
DR eggNOG; ENOG502QR4I; Eukaryota.
DR InParanoid; Q8VD26; -.
DR OrthoDB; 1506124at2759; -.
DR PhylomeDB; Q8VD26; -.
DR BioGRID-ORCS; 70209; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q8VD26; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8VD26; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI.
DR InterPro; IPR022227; DUF3754.
DR Pfam; PF12576; DUF3754; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..458
FT /note="Transmembrane protein 143"
FT /id="PRO_0000285959"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 329
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..15
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024933"
FT VAR_SEQ 1..5
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024934"
FT VAR_SEQ 6..7
FT /note="WL -> MF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024935"
FT VAR_SEQ 186..255
FT /note="VTINLDQYIYIQFWALGQRVGQMPHKSSVGSKRGFFRKLPPVERRYFKRVVL
FT AARTKGGHLVLKSFKDTP -> EILQACGVGCPDERRAPGPEELQGYPAGGLRAAAAGA
FT EGAHARAAARPAQPHVGGLRRHDLRQRGHGDTV (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024936"
FT VAR_SEQ 256..458
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024937"
FT CONFLICT 294
FT /note="G -> S (in Ref. 1; BAC39951)"
FT /evidence="ECO:0000305"
FT CONFLICT 430
FT /note="L -> P (in Ref. 1; BAC30266/BAC39951)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 458 AA; 51596 MW; 3BF14C4695056B2F CRC64;
MTVARWLRLW ERGQAMLHVT WGSKVRLWSL VPALLGTPRA LSSLENRMGV YRKMWNPKEP
CDWAQQYRER FIPFSKEQLL RLLIQEFHSS PAERAALEAF SAHVDFCTLF HYHQLLARLQ
ALYDPINPDR ETLDQPSLTD PERLSSEKDV LQALRPLLAQ ANFSPLSEDA LAYALVVHHP
QDEVQVTINL DQYIYIQFWA LGQRVGQMPH KSSVGSKRGF FRKLPPVERR YFKRVVLAAR
TKGGHLVLKS FKDTPLEGLE QLLPELKVRT PVLQRALLNL MLVVSGVMIF VNVGMVILSD
LKMATSLLLL LFAAFMGVKA SKVFGQRRSA QALELAHVLY YRSTSNNSEL LSALALRAQE
EHIKEALLAH SFLARRPGGS QGKPEETSRW LQSEVESWLL AQSGCDVTFN GPRALAHLQA
LTPSLGLFPL PELPQLDPMV LGTPEATQAA LGSSYPSP
