TM144_HUMAN
ID TM144_HUMAN Reviewed; 345 AA.
AC Q7Z5S9; D3DP24; Q49A05; Q9NUT3;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Transmembrane protein 144;
GN Name=TMEM144;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Hippocampus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q7Z5S9; Q13520: AQP6; NbExp=3; IntAct=EBI-12876358, EBI-13059134;
CC Q7Z5S9; O15552: FFAR2; NbExp=3; IntAct=EBI-12876358, EBI-2833872;
CC Q7Z5S9; Q9BSE4: HERPUD2; NbExp=3; IntAct=EBI-12876358, EBI-2868124;
CC Q7Z5S9; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-12876358, EBI-17280858;
CC Q7Z5S9; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-12876358, EBI-6268651;
CC Q7Z5S9; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-12876358, EBI-10982110;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7Z5S9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z5S9-2; Sequence=VSP_025850, VSP_025851;
CC -!- SIMILARITY: Belongs to the TMEM144 family. {ECO:0000305}.
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DR EMBL; AK002017; BAA92037.1; -; mRNA.
DR EMBL; CH471056; EAX04859.1; -; Genomic_DNA.
DR EMBL; CH471056; EAX04860.1; -; Genomic_DNA.
DR EMBL; CH471056; EAX04861.1; -; Genomic_DNA.
DR EMBL; CH471056; EAX04862.1; -; Genomic_DNA.
DR EMBL; BC036551; AAH36551.1; -; mRNA.
DR EMBL; BC048117; AAH48117.1; -; mRNA.
DR EMBL; BC054487; AAH54487.1; -; mRNA.
DR EMBL; BC060875; AAH60875.1; -; mRNA.
DR CCDS; CCDS3799.1; -. [Q7Z5S9-1]
DR RefSeq; NP_060812.2; NM_018342.4. [Q7Z5S9-1]
DR RefSeq; XP_005263167.1; XM_005263110.1. [Q7Z5S9-1]
DR RefSeq; XP_005263169.1; XM_005263112.3. [Q7Z5S9-1]
DR RefSeq; XP_006714317.1; XM_006714254.1. [Q7Z5S9-1]
DR RefSeq; XP_016863855.1; XM_017008366.1. [Q7Z5S9-1]
DR AlphaFoldDB; Q7Z5S9; -.
DR BioGRID; 120596; 8.
DR IntAct; Q7Z5S9; 7.
DR MINT; Q7Z5S9; -.
DR STRING; 9606.ENSP00000296529; -.
DR iPTMnet; Q7Z5S9; -.
DR PhosphoSitePlus; Q7Z5S9; -.
DR BioMuta; TMEM144; -.
DR DMDM; 74738741; -.
DR MassIVE; Q7Z5S9; -.
DR PaxDb; Q7Z5S9; -.
DR PeptideAtlas; Q7Z5S9; -.
DR PRIDE; Q7Z5S9; -.
DR Antibodypedia; 28144; 32 antibodies from 13 providers.
DR DNASU; 55314; -.
DR Ensembl; ENST00000296529.11; ENSP00000296529.6; ENSG00000164124.11. [Q7Z5S9-1]
DR Ensembl; ENST00000514558.5; ENSP00000426211.1; ENSG00000164124.11. [Q7Z5S9-2]
DR GeneID; 55314; -.
DR KEGG; hsa:55314; -.
DR MANE-Select; ENST00000296529.11; ENSP00000296529.6; NM_018342.5; NP_060812.2.
DR UCSC; uc003ipx.4; human. [Q7Z5S9-1]
DR CTD; 55314; -.
DR GeneCards; TMEM144; -.
DR HGNC; HGNC:25633; TMEM144.
DR HPA; ENSG00000164124; Tissue enriched (brain).
DR neXtProt; NX_Q7Z5S9; -.
DR OpenTargets; ENSG00000164124; -.
DR PharmGKB; PA144596252; -.
DR VEuPathDB; HostDB:ENSG00000164124; -.
DR eggNOG; ENOG502QR0F; Eukaryota.
DR GeneTree; ENSGT00390000012574; -.
DR HOGENOM; CLU_031844_1_0_1; -.
DR InParanoid; Q7Z5S9; -.
DR OMA; GALWCTG; -.
DR OrthoDB; 960736at2759; -.
DR PhylomeDB; Q7Z5S9; -.
DR TreeFam; TF313673; -.
DR PathwayCommons; Q7Z5S9; -.
DR SignaLink; Q7Z5S9; -.
DR BioGRID-ORCS; 55314; 11 hits in 1080 CRISPR screens.
DR ChiTaRS; TMEM144; human.
DR GenomeRNAi; 55314; -.
DR Pharos; Q7Z5S9; Tdark.
DR PRO; PR:Q7Z5S9; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q7Z5S9; protein.
DR Bgee; ENSG00000164124; Expressed in corpus callosum and 161 other tissues.
DR ExpressionAtlas; Q7Z5S9; baseline and differential.
DR Genevisible; Q7Z5S9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR010651; Sugar_transport.
DR InterPro; IPR012435; TMEM144.
DR PANTHER; PTHR16119; PTHR16119; 1.
DR Pfam; PF07857; TMEM144; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..345
FT /note="Transmembrane protein 144"
FT /id="PRO_0000288971"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 167..169
FT /note="INT -> SIV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025850"
FT VAR_SEQ 170..345
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025851"
FT VARIANT 157
FT /note="D -> G (in dbSNP:rs34277853)"
FT /id="VAR_032544"
FT CONFLICT 89
FT /note="I -> V (in Ref. 1; BAA92037)"
FT /evidence="ECO:0000305"
FT CONFLICT 344
FT /note="K -> E (in Ref. 1; BAA92037)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 345 AA; 37653 MW; 0B25B7B8FB970B6C CRC64;
MSNNGADLTF GYISCFVAIL LFGSNFVPLK KFDTGDGMFL QWVLCAAIWL VALVVNLILH
CPKFWPFAML GGCIWATGNI AVVPIIKTIG LGLGILIWGS FNALTGWASS RFGWFGLDAE
EVSNPLLNYI GAGLSVVSAF IFLFIKSEIP NNTCSMDTTP LITEHVINTT QDPCSWVDKL
STVHHRIVGC SLAVISGVLY GSTFVPIIYI KDHSKRNDSI YAGASQYDLD YVFAHFSGIF
LTSTVYFLAY CIAMKNSPKL YPEAVLPGFL SGVLWAIATC CWFIANHSLS AVVSFPIITA
GPGFIAAMWG IFMFKEIKGL QNYLLMILAF CIILTGALCT AFSKI
