TM144_MOUSE
ID TM144_MOUSE Reviewed; 348 AA.
AC Q8VEH0; Q9CYC7;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Transmembrane protein 144;
GN Name=Tmem144;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM144 family. {ECO:0000305}.
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DR EMBL; AK017808; BAB30945.1; -; mRNA.
DR EMBL; AK079384; BAC37628.1; -; mRNA.
DR EMBL; BC018493; AAH18493.1; -; mRNA.
DR CCDS; CCDS17421.1; -.
DR RefSeq; NP_081771.2; NM_027495.4.
DR RefSeq; XP_006502120.1; XM_006502057.3.
DR RefSeq; XP_006502121.1; XM_006502058.3.
DR RefSeq; XP_006502122.1; XM_006502059.3.
DR RefSeq; XP_011238526.1; XM_011240224.2.
DR AlphaFoldDB; Q8VEH0; -.
DR STRING; 10090.ENSMUSP00000029568; -.
DR iPTMnet; Q8VEH0; -.
DR PhosphoSitePlus; Q8VEH0; -.
DR PaxDb; Q8VEH0; -.
DR PRIDE; Q8VEH0; -.
DR ProteomicsDB; 259533; -.
DR Antibodypedia; 28144; 32 antibodies from 13 providers.
DR DNASU; 70652; -.
DR Ensembl; ENSMUST00000029568; ENSMUSP00000029568; ENSMUSG00000027956.
DR Ensembl; ENSMUST00000168038; ENSMUSP00000127837; ENSMUSG00000027956.
DR GeneID; 70652; -.
DR KEGG; mmu:70652; -.
DR UCSC; uc008pnw.1; mouse.
DR CTD; 55314; -.
DR MGI; MGI:1917902; Tmem144.
DR VEuPathDB; HostDB:ENSMUSG00000027956; -.
DR eggNOG; ENOG502QR0F; Eukaryota.
DR GeneTree; ENSGT00390000012574; -.
DR HOGENOM; CLU_031844_1_0_1; -.
DR InParanoid; Q8VEH0; -.
DR OMA; GALWCTG; -.
DR OrthoDB; 960736at2759; -.
DR PhylomeDB; Q8VEH0; -.
DR TreeFam; TF313673; -.
DR BioGRID-ORCS; 70652; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Tmem144; mouse.
DR PRO; PR:Q8VEH0; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8VEH0; protein.
DR Bgee; ENSMUSG00000027956; Expressed in spermatid and 146 other tissues.
DR ExpressionAtlas; Q8VEH0; baseline and differential.
DR Genevisible; Q8VEH0; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR010651; Sugar_transport.
DR InterPro; IPR012435; TMEM144.
DR PANTHER; PTHR16119; PTHR16119; 1.
DR Pfam; PF07857; TMEM144; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..348
FT /note="Transmembrane protein 144"
FT /id="PRO_0000288972"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 165
FT /note="P -> H (in Ref. 1; BAB30945)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 348 AA; 37771 MW; 0A10220D9EEC0451 CRC64;
MSSNATDLTT GYLSSAAAIL LFGSNFVPLK KYDTGDGMFL QWVLCAAIWL VALVVNLILH
CPKFWPFAML GGCIWATGNI AVVPIIKTIG LGLGILIWGS FNTLTGWASS RFGWFGMDAE
EVSKPMLNYV GAGLSVVSAL TFLFIKSEIP NNPGSSDTTP LMTEPVINRT EDRSADSSWV
DRLSTTYHRI VGCSLAVISG ILYGSTFVPI IYIKDHSRRN DSMYAGASQY DLDYVFAHSS
GIFLTSTVYF VAYCVAMKNR PKLYPEAVLP GLLSGVLWAI ATCCWFIANH SLSAVISFPI
ITAGPGLIAA LWGILIFKEI QGLRNYLLMM LAFCIILAGA LCTAFSKV
