TM145_HUMAN
ID TM145_HUMAN Reviewed; 493 AA.
AC Q8NBT3;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Transmembrane protein 145;
GN Name=TMEM145;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retinoblastoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK075286; BAC11522.1; -; mRNA.
DR EMBL; AC024078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS12603.1; -.
DR RefSeq; NP_775904.2; NM_173633.2.
DR AlphaFoldDB; Q8NBT3; -.
DR STRING; 9606.ENSP00000301204; -.
DR GlyGen; Q8NBT3; 2 sites.
DR iPTMnet; Q8NBT3; -.
DR PhosphoSitePlus; Q8NBT3; -.
DR BioMuta; TMEM145; -.
DR DMDM; 296452935; -.
DR MassIVE; Q8NBT3; -.
DR PaxDb; Q8NBT3; -.
DR PeptideAtlas; Q8NBT3; -.
DR PRIDE; Q8NBT3; -.
DR ProteomicsDB; 72821; -.
DR Antibodypedia; 58359; 58 antibodies from 18 providers.
DR DNASU; 284339; -.
DR Ensembl; ENST00000301204.8; ENSP00000301204.2; ENSG00000167619.13.
DR GeneID; 284339; -.
DR KEGG; hsa:284339; -.
DR MANE-Select; ENST00000301204.8; ENSP00000301204.2; NM_173633.3; NP_775904.2.
DR UCSC; uc002otk.2; human.
DR CTD; 284339; -.
DR GeneCards; TMEM145; -.
DR HGNC; HGNC:26912; TMEM145.
DR HPA; ENSG00000167619; Group enriched (brain, pituitary gland, retina).
DR neXtProt; NX_Q8NBT3; -.
DR OpenTargets; ENSG00000167619; -.
DR PharmGKB; PA144596253; -.
DR VEuPathDB; HostDB:ENSG00000167619; -.
DR eggNOG; KOG1388; Eukaryota.
DR eggNOG; KOG4290; Eukaryota.
DR GeneTree; ENSGT00940000153981; -.
DR HOGENOM; CLU_021549_3_0_1; -.
DR InParanoid; Q8NBT3; -.
DR OMA; YTWSGCA; -.
DR OrthoDB; 1155958at2759; -.
DR PhylomeDB; Q8NBT3; -.
DR TreeFam; TF314975; -.
DR PathwayCommons; Q8NBT3; -.
DR SignaLink; Q8NBT3; -.
DR BioGRID-ORCS; 284339; 10 hits in 1071 CRISPR screens.
DR GenomeRNAi; 284339; -.
DR Pharos; Q8NBT3; Tdark.
DR PRO; PR:Q8NBT3; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NBT3; protein.
DR Bgee; ENSG00000167619; Expressed in right hemisphere of cerebellum and 96 other tissues.
DR ExpressionAtlas; Q8NBT3; baseline and differential.
DR Genevisible; Q8NBT3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR InterPro; IPR019336; Intimal_thickness-rel_rcpt.
DR Pfam; PF10192; GpcrRhopsn4; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..493
FT /note="Transmembrane protein 145"
FT /id="PRO_0000280355"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 464..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 444
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 256
FT /note="L -> M (in dbSNP:rs7254227)"
FT /id="VAR_060400"
FT CONFLICT 281
FT /note="S -> P (in Ref. 1; BAC11522)"
FT /evidence="ECO:0000305"
FT CONFLICT 467
FT /note="S -> F (in Ref. 1; BAC11522)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 493 AA; 55534 MW; 316BB050EAC5285A CRC64;
MEPLRAPALR RLLPPLLLLL LSLPPRARAK YVRGNLSSKE DWVFLTRFCF LSDYGRLDFR
FRYPEAKCCQ NILLYFDDPS QWPAVYKAGD KDCLAKESVI RPENNQVINL TTQYAWSGCQ
VVSEEGTRYL SCSSGRSFRS GDGLQLEYEM VLTNGKSFWT RHFSADEFGI LETDVTFLLI
FILIFFLSCY FGYLLKGRQL LHTTYKMFMA AAGVEVLSLL FFCIYWGQYA TDGIGNESVK
ILAKLLFSSS FLIFLLMLIL LGKGFTVTRG RISHAGSVKL SVYMTLYTLT HVVLLIYEAE
FFDPGQVLYT YESPAGYGLI GLQVAAYVWF CYAVLVSLRH FPEKQPFYVP FFAAYTLWFF
AVPVMALIAN FGIPKWAREK IVNGIQLGIH LYAHGVFLIM TRPSAANKNF PYHVRTSQIA
SAGVPGPGGS QSADKAFPQH VYGNVTFISD SVPNFTELFS IPPPATSPLP RAAPDSGLPL
FRDLRPPGPL RDL
