ID   TM147_DANRE             Reviewed;         225 AA.
AC   Q6DGL7;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Transmembrane protein 147;
GN   Name=tmem147; ORFNames=zgc:92863;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for the translocation in the endoplasmic reticulum
CC       and the biogenesis of multi-pass membrane proteins.
CC       {ECO:0000250|UniProtKB:Q9BVK8}.
CC   -!- SUBUNIT: Component of the ribosome-associated endoplasmic reticulum
CC       translocon complex. {ECO:0000250|UniProtKB:Q9BVK8}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9BVK8}; Multi-pass membrane protein
CC       {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:I6VSD2}; Multi-pass
CC       membrane protein {ECO:0000255}.
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DR   EMBL; BC076325; AAH76325.1; -; mRNA.
DR   RefSeq; NP_001002484.1; NM_001002484.1.
DR   AlphaFoldDB; Q6DGL7; -.
DR   SMR; Q6DGL7; -.
DR   STRING; 7955.ENSDARP00000058382; -.
DR   PaxDb; Q6DGL7; -.
DR   GeneID; 436757; -.
DR   KEGG; dre:436757; -.
DR   CTD; 10430; -.
DR   ZFIN; ZDB-GENE-040718-187; tmem147.
DR   eggNOG; KOG3236; Eukaryota.
DR   InParanoid; Q6DGL7; -.
DR   OrthoDB; 1388283at2759; -.
DR   PhylomeDB; Q6DGL7; -.
DR   PRO; PR:Q6DGL7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   InterPro; IPR019164; TMEM147.
DR   PANTHER; PTHR12869; PTHR12869; 1.
DR   Pfam; PF09767; DUF2053; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..225
FT                   /note="Transmembrane protein 147"
FT                   /id="PRO_0000271704"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   225 AA;  25459 MW;  10F51C184631DDBE CRC64;
     MTLFHFGNCF SLAYFPYFIT YKCSGLSEYN AFWRCVQAGA TYLFVRLCKM LFLATFFPTW
     EGGAGVYDFV GEFMKATVDM ADLLGLHLVM SRNAGKGEYK IMVAAMGWAT AELIMSRCIP
     LWVGARGIEF DWKYIQMSFD SNISLVHYIA MAAVVWMFTR YDLPKSFRLP VAILLGLCVY
     KGFLMELFVH VFLLGSWTAL LVKAVLTGAI SLCSLFLFVT LVHSN