ID   TM147_XENLA             Reviewed;         225 AA.
AC   Q6DFI2;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Transmembrane protein 147;
GN   Name=tmem147;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for the translocation in the endoplasmic reticulum
CC       and the biogenesis of multi-pass membrane proteins.
CC       {ECO:0000250|UniProtKB:Q9BVK8}.
CC   -!- SUBUNIT: Component of the ribosome-associated endoplasmic reticulum
CC       translocon complex. {ECO:0000250|UniProtKB:Q9BVK8}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9BVK8}; Multi-pass membrane protein
CC       {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:I6VSD2}; Multi-pass
CC       membrane protein {ECO:0000255}.
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DR   EMBL; BC076755; AAH76755.1; -; mRNA.
DR   RefSeq; NP_001086527.1; NM_001093058.1.
DR   AlphaFoldDB; Q6DFI2; -.
DR   SMR; Q6DFI2; -.
DR   DNASU; 446362; -.
DR   GeneID; 446362; -.
DR   KEGG; xla:446362; -.
DR   CTD; 446362; -.
DR   Xenbase; XB-GENE-970272; tmem147.S.
DR   OMA; MKSTVDL; -.
DR   OrthoDB; 1388283at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 446362; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   InterPro; IPR019164; TMEM147.
DR   PANTHER; PTHR12869; PTHR12869; 1.
DR   Pfam; PF09767; DUF2053; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..225
FT                   /note="Transmembrane protein 147"
FT                   /id="PRO_0000271705"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   225 AA;  25407 MW;  C03F1CB082C023C0 CRC64;
     MTLFHFGNCF ALAYFPYFIT YKCSGLSEYN AFWRCVQAGA TYLCVQLCKM LFLATFFPTW
     EGAAGAYDFI GEFMKATVDL ADLLGLHLVM SRNAGKGEYK IMVAAMGWAT AELVMSRCLP
     LWVGARGIEF DWKYIQMSID SNISLVHYMA VAALVWMWTR YDLPTHYRLP VTVLLGLSMY
     KAFLMDCFVH MFIMGSWTAL LLKAVITGVL SLSCLTLFVS LVHGN