ID   TM147_XENTR             Reviewed;         225 AA.
AC   Q28FY5; Q6DFP6;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Transmembrane protein 147;
GN   Name=tmem147; ORFNames=TGas054a07.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for the translocation in the endoplasmic reticulum
CC       and the biogenesis of multi-pass membrane proteins.
CC       {ECO:0000250|UniProtKB:Q9BVK8}.
CC   -!- SUBUNIT: Component of the ribosome-associated endoplasmic reticulum
CC       translocon complex. {ECO:0000250|UniProtKB:Q9BVK8}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9BVK8}; Multi-pass membrane protein
CC       {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:I6VSD2}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q28FY5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q28FY5-2; Sequence=VSP_022330;
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DR   EMBL; CR761674; CAJ81993.1; -; mRNA.
DR   EMBL; BC076688; AAH76688.1; -; mRNA.
DR   RefSeq; NP_001005017.1; NM_001005017.1. [Q28FY5-2]
DR   AlphaFoldDB; Q28FY5; -.
DR   SMR; Q28FY5; -.
DR   STRING; 8364.ENSXETP00000014925; -.
DR   DNASU; 448523; -.
DR   GeneID; 448523; -.
DR   KEGG; xtr:448523; -.
DR   CTD; 10430; -.
DR   Xenbase; XB-GENE-970269; tmem147.
DR   eggNOG; KOG3236; Eukaryota.
DR   InParanoid; Q28FY5; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   InterPro; IPR019164; TMEM147.
DR   PANTHER; PTHR12869; PTHR12869; 1.
DR   Pfam; PF09767; DUF2053; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Endoplasmic reticulum; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..225
FT                   /note="Transmembrane protein 147"
FT                   /id="PRO_0000271706"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..49
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_022330"
SQ   SEQUENCE   225 AA;  25417 MW;  42B8636623EE33DE CRC64;
     MTLFHFGNCF ALAYFPYFIT YKCSGLSEYN AFWRCVQAGA TYLCVQLCKM LFLATFFPTW
     EGAVGAYDFI GEFMKATVDL ADLLGLHLVM SRNAGKGEYK IMVAAMGWAT AELVMSRCLP
     LWVGARGIEF DWKYIQMSID SNISLVHYMA VAALVWMWTR YDLPTHYRLP VTVLLGLSMY
     KAFLMDCFVH IFIMGSWTAL LLKAVITGVL SLSCLTLFVS LVHGN