ID   TM14A_BOVIN             Reviewed;          99 AA.
AC   P56982; Q3ZC76;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Transmembrane protein 14A;
GN   Name=TMEM14A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits apoptosis via negative regulation of the
CC       mitochondrial outer membrane permeabilization involved in apoptotic
CC       signaling pathway. {ECO:0000250|UniProtKB:Q9Y6G1}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:Q9Y6G1}; Multi-pass membrane protein
CC       {ECO:0000255}. Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9Y6G1}.
CC   -!- SIMILARITY: Belongs to the TMEM14 family. {ECO:0000305}.
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DR   EMBL; BC102864; AAI02865.1; -; mRNA.
DR   RefSeq; NP_001029551.1; NM_001034379.1.
DR   RefSeq; XP_005223462.1; XM_005223405.3.
DR   RefSeq; XP_005223463.1; XM_005223406.3.
DR   RefSeq; XP_005223464.1; XM_005223407.3.
DR   RefSeq; XP_010816477.1; XM_010818175.1.
DR   AlphaFoldDB; P56982; -.
DR   STRING; 9913.ENSBTAP00000006857; -.
DR   PaxDb; P56982; -.
DR   PRIDE; P56982; -.
DR   Ensembl; ENSBTAT00000006857; ENSBTAP00000006857; ENSBTAG00000005206.
DR   Ensembl; ENSBTAT00000074113; ENSBTAP00000064619; ENSBTAG00000005206.
DR   GeneID; 510383; -.
DR   KEGG; bta:510383; -.
DR   CTD; 28978; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005206; -.
DR   VGNC; VGNC:35979; TMEM14A.
DR   eggNOG; KOG4267; Eukaryota.
DR   GeneTree; ENSGT00940000158206; -.
DR   HOGENOM; CLU_096652_4_3_1; -.
DR   InParanoid; P56982; -.
DR   OMA; MGTRYKK; -.
DR   OrthoDB; 1642026at2759; -.
DR   TreeFam; TF323345; -.
DR   Proteomes; UP000009136; Chromosome 23.
DR   Bgee; ENSBTAG00000005206; Expressed in caput epididymis and 102 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0070453; P:regulation of heme biosynthetic process; IBA:GO_Central.
DR   Gene3D; 1.10.10.1740; -; 1.
DR   InterPro; IPR005349; TMEM14.
DR   InterPro; IPR044890; TMEM14_sf.
DR   PANTHER; PTHR12668; PTHR12668; 1.
DR   Pfam; PF03647; Tmemb_14; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Mitochondrion; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..99
FT                   /note="Transmembrane protein 14A"
FT                   /id="PRO_0000221168"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   99 AA;  10734 MW;  CF61C1B623299204 CRC64;
     MDLIGFGYAA LVTFGSILGY KRRGGVLSLI AGLFVGFLAG YGAYRVSNDK RDVKLSLFTA
     FFLATIMGVR FKRSKKIMPA GLVAGLSLLM ILRLVLLLL