TM14A_MOUSE
ID TM14A_MOUSE Reviewed; 99 AA.
AC P56983; Q8JZZ3;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2003, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Transmembrane protein 14A;
GN Name=Tmem14a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibits apoptosis via negative regulation of the
CC mitochondrial outer membrane permeabilization involved in apoptotic
CC signaling pathway. {ECO:0000250|UniProtKB:Q9Y6G1}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000250|UniProtKB:Q9Y6G1}; Multi-pass membrane protein
CC {ECO:0000255}. Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9Y6G1}.
CC -!- SIMILARITY: Belongs to the TMEM14 family. {ECO:0000305}.
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DR EMBL; BC034768; AAH34768.1; -; mRNA.
DR EMBL; BC060034; AAH60034.1; -; mRNA.
DR CCDS; CCDS35523.1; -.
DR RefSeq; NP_001277608.1; NM_001290679.1.
DR RefSeq; NP_083674.2; NM_029398.3.
DR AlphaFoldDB; P56983; -.
DR SMR; P56983; -.
DR STRING; 10090.ENSMUSP00000027065; -.
DR PhosphoSitePlus; P56983; -.
DR PaxDb; P56983; -.
DR PRIDE; P56983; -.
DR ProteomicsDB; 258903; -.
DR Antibodypedia; 30922; 37 antibodies from 11 providers.
DR Ensembl; ENSMUST00000027065; ENSMUSP00000027065; ENSMUSG00000025933.
DR GeneID; 75712; -.
DR KEGG; mmu:75712; -.
DR UCSC; uc007alj.2; mouse.
DR CTD; 28978; -.
DR MGI; MGI:1922962; Tmem14a.
DR VEuPathDB; HostDB:ENSMUSG00000025933; -.
DR eggNOG; KOG4267; Eukaryota.
DR GeneTree; ENSGT00940000158206; -.
DR HOGENOM; CLU_096652_4_3_1; -.
DR InParanoid; P56983; -.
DR OMA; MGTRYKK; -.
DR OrthoDB; 1642026at2759; -.
DR PhylomeDB; P56983; -.
DR TreeFam; TF323345; -.
DR BioGRID-ORCS; 75712; 5 hits in 73 CRISPR screens.
DR PRO; PR:P56983; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; P56983; protein.
DR Bgee; ENSMUSG00000025933; Expressed in prefrontal cortex and 216 other tissues.
DR ExpressionAtlas; P56983; baseline and differential.
DR Genevisible; P56983; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
DR GO; GO:0070453; P:regulation of heme biosynthetic process; IBA:GO_Central.
DR Gene3D; 1.10.10.1740; -; 1.
DR InterPro; IPR005349; TMEM14.
DR InterPro; IPR044890; TMEM14_sf.
DR PANTHER; PTHR12668; PTHR12668; 1.
DR Pfam; PF03647; Tmemb_14; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Mitochondrion; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..99
FT /note="Transmembrane protein 14A"
FT /id="PRO_0000221170"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 99 AA; 10594 MW; 74E8AA4B2128A707 CRC64;
MDLIGFGYAA LVTIGSVLGY KRRGGVPSLI AGLSVGLLAG YGAYRVSNDR RDVKVSLFTA
FFLATIMGVR FKRSKKVMPA GLVAGLSLMM ILRLVLLLL
