ID   TM14A_PIG               Reviewed;          99 AA.
AC   P56984;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Transmembrane protein 14A;
GN   Name=TMEM14A;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Fahrenkrug S.C., Freking B.A., Rohrer G.A., Smith T.P.L., Casas E.,
RA   Stone R.T., Heaton M.P., Grosse W.M., Bennett G.A., Laegreid W.W.,
RA   Keele J.W.;
RT   "Design and use of two pooled tissue normalized cDNA libraries for EST
RT   discovery in swine.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   RECONSTRUCTION FROM ESTS.
RA   Bairoch A.;
RL   Unpublished observations (AUG-2000).
CC   -!- FUNCTION: Inhibits apoptosis via negative regulation of the
CC       mitochondrial outer membrane permeabilization involved in apoptotic
CC       signaling pathway. {ECO:0000250|UniProtKB:Q9Y6G1}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:Q9Y6G1}; Multi-pass membrane protein
CC       {ECO:0000255}. Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9Y6G1}.
CC   -!- SIMILARITY: Belongs to the TMEM14 family. {ECO:0000305}.
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DR   EMBL; BE233236; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_003128844.1; XM_003128796.3.
DR   RefSeq; XP_003482377.1; XM_003482329.3.
DR   RefSeq; XP_005666526.1; XM_005666469.2.
DR   RefSeq; XP_013833906.1; XM_013978452.1.
DR   AlphaFoldDB; P56984; -.
DR   SMR; P56984; -.
DR   STRING; 9823.ENSSSCP00000002830; -.
DR   PaxDb; P56984; -.
DR   PRIDE; P56984; -.
DR   Ensembl; ENSSSCT00000002909; ENSSSCP00000002830; ENSSSCG00000002622.
DR   Ensembl; ENSSSCT00005029139; ENSSSCP00005017790; ENSSSCG00005018506.
DR   Ensembl; ENSSSCT00005029151; ENSSSCP00005017799; ENSSSCG00005018506.
DR   Ensembl; ENSSSCT00015073756; ENSSSCP00015029616; ENSSSCG00015055381.
DR   Ensembl; ENSSSCT00025067316; ENSSSCP00025028809; ENSSSCG00025049444.
DR   Ensembl; ENSSSCT00030068883; ENSSSCP00030031462; ENSSSCG00030049402.
DR   Ensembl; ENSSSCT00035088107; ENSSSCP00035036806; ENSSSCG00035065416.
DR   Ensembl; ENSSSCT00040007054; ENSSSCP00040002798; ENSSSCG00040005339.
DR   Ensembl; ENSSSCT00045005175; ENSSSCP00045003430; ENSSSCG00045003203.
DR   Ensembl; ENSSSCT00050001590; ENSSSCP00050000446; ENSSSCG00050001339.
DR   Ensembl; ENSSSCT00055026043; ENSSSCP00055020696; ENSSSCG00055013247.
DR   Ensembl; ENSSSCT00060012938; ENSSSCP00060004894; ENSSSCG00060010005.
DR   Ensembl; ENSSSCT00065045455; ENSSSCP00065019489; ENSSSCG00065033455.
DR   Ensembl; ENSSSCT00070017587; ENSSSCP00070014579; ENSSSCG00070009067.
DR   Ensembl; ENSSSCT00070017596; ENSSSCP00070014587; ENSSSCG00070009067.
DR   Ensembl; ENSSSCT00070017603; ENSSSCP00070014592; ENSSSCG00070009067.
DR   GeneID; 100512176; -.
DR   KEGG; ssc:100512176; -.
DR   CTD; 28978; -.
DR   VGNC; VGNC:94094; TMEM14A.
DR   eggNOG; KOG4267; Eukaryota.
DR   GeneTree; ENSGT00940000158206; -.
DR   HOGENOM; CLU_096652_4_3_1; -.
DR   InParanoid; P56984; -.
DR   OMA; MGTRYKK; -.
DR   OrthoDB; 1642026at2759; -.
DR   TreeFam; TF323345; -.
DR   Proteomes; UP000008227; Chromosome 7.
DR   Proteomes; UP000314985; Chromosome 7.
DR   Bgee; ENSSSCG00000002622; Expressed in epididymis and 45 other tissues.
DR   ExpressionAtlas; P56984; baseline and differential.
DR   Genevisible; P56984; SS.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0070453; P:regulation of heme biosynthetic process; IBA:GO_Central.
DR   Gene3D; 1.10.10.1740; -; 1.
DR   InterPro; IPR005349; TMEM14.
DR   InterPro; IPR044890; TMEM14_sf.
DR   PANTHER; PTHR12668; PTHR12668; 1.
DR   Pfam; PF03647; Tmemb_14; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Mitochondrion; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..99
FT                   /note="Transmembrane protein 14A"
FT                   /id="PRO_0000221171"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   99 AA;  10717 MW;  D416ADAED9F34AE4 CRC64;
     MDLIGFGYAA LVTFGSILGY KRRGGVPSLI AGLFVGFLAG YGAYRVSLDK RDVKLSLFTA
     FFLATIMGVR FKRSKKIMPA GLVAGLSLLM ILRLVLLLL