TM14C_BOVIN
ID TM14C_BOVIN Reviewed; 114 AA.
AC Q3ZCI1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Transmembrane protein 14C;
GN Name=TMEM14C;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP CLEAVAGE OF INITIATOR METHIONINE, SUBCELLULAR LOCATION, AND MASS
RP SPECTROMETRY.
RX PubMed=17060615; DOI=10.1073/pnas.0607719103;
RA Carroll J., Fearnley I.M., Walker J.E.;
RT "Definition of the mitochondrial proteome by measurement of molecular
RT masses of membrane proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:16170-16175(2006).
CC -!- FUNCTION: Required for normal heme biosynthesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000269|PubMed:17060615}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:17060615}.
CC -!- MASS SPECTROMETRY: Mass=11604.4; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:17060615};
CC -!- SIMILARITY: Belongs to the TMEM14 family. {ECO:0000305}.
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DR EMBL; BC102229; AAI02230.1; -; mRNA.
DR RefSeq; NP_001030514.1; NM_001035437.1.
DR AlphaFoldDB; Q3ZCI1; -.
DR STRING; 9913.ENSBTAP00000007635; -.
DR PaxDb; Q3ZCI1; -.
DR PRIDE; Q3ZCI1; -.
DR Ensembl; ENSBTAT00000007635; ENSBTAP00000007635; ENSBTAG00000005808.
DR GeneID; 613802; -.
DR KEGG; bta:613802; -.
DR CTD; 51522; -.
DR VEuPathDB; HostDB:ENSBTAG00000005808; -.
DR eggNOG; KOG4267; Eukaryota.
DR GeneTree; ENSGT00940000154772; -.
DR HOGENOM; CLU_096652_4_0_1; -.
DR InParanoid; Q3ZCI1; -.
DR OMA; TYNRYLM; -.
DR OrthoDB; 1642026at2759; -.
DR TreeFam; TF323345; -.
DR Proteomes; UP000009136; Chromosome 23.
DR Bgee; ENSBTAG00000005808; Expressed in cardiac ventricle and 103 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006839; P:mitochondrial transport; IEA:Ensembl.
DR GO; GO:0071705; P:nitrogen compound transport; IEA:Ensembl.
DR GO; GO:0071702; P:organic substance transport; IEA:Ensembl.
DR GO; GO:0070453; P:regulation of heme biosynthetic process; IBA:GO_Central.
DR Gene3D; 1.10.10.1740; -; 1.
DR InterPro; IPR005349; TMEM14.
DR InterPro; IPR044890; TMEM14_sf.
DR PANTHER; PTHR12668; PTHR12668; 1.
DR Pfam; PF03647; Tmemb_14; 1.
PE 1: Evidence at protein level;
KW Heme biosynthesis; Membrane; Mitochondrion; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:17060615"
FT CHAIN 2..114
FT /note="Transmembrane protein 14C"
FT /id="PRO_0000328447"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 114 AA; 11735 MW; 5E71B8329BC5E360 CRC64;
MPKDSGPLVP LHWLGFGYAA LVASGGIIGY AKAGSVPSLA AGLLFGGLAG LGSYQLSQDP
KNIWLFLVTS GTLAGIMGMR FYNSRKFMPA GLIAGASLLM VVKLGISALS KPHQ
