ID   TM14C_DANRE             Reviewed;         107 AA.
AC   Q0P436;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Transmembrane protein 14C;
GN   Name=tmem14c; Synonyms=c6orf53; ORFNames=zgc:153439;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larval eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19656490; DOI=10.1016/j.cmet.2009.06.012;
RA   Nilsson R., Schultz I.J., Pierce E.L., Soltis K.A., Naranuntarat A.,
RA   Ward D.M., Baughman J.M., Paradkar P.N., Kingsley P.D., Culotta V.C.,
RA   Kaplan J., Palis J., Paw B.H., Mootha V.K.;
RT   "Discovery of genes essential for heme biosynthesis through large-scale
RT   gene expression analysis.";
RL   Cell Metab. 10:119-130(2009).
CC   -!- FUNCTION: Required for normal heme biosynthesis. {ECO:0000250,
CC       ECO:0000269|PubMed:19656490}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein results in
CC       profound anemia without affecting erythroid specification.
CC       {ECO:0000269|PubMed:19656490}.
CC   -!- SIMILARITY: Belongs to the TMEM14 family. {ECO:0000305}.
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DR   EMBL; BC122294; AAI22295.1; -; mRNA.
DR   RefSeq; NP_001038903.1; NM_001045438.1.
DR   AlphaFoldDB; Q0P436; -.
DR   STRING; 7955.ENSDARP00000100331; -.
DR   PaxDb; Q0P436; -.
DR   GeneID; 751728; -.
DR   KEGG; dre:751728; -.
DR   CTD; 751728; -.
DR   ZFIN; ZDB-GENE-060825-156; tmem14ca.
DR   eggNOG; KOG4267; Eukaryota.
DR   InParanoid; Q0P436; -.
DR   OrthoDB; 1642026at2759; -.
DR   PhylomeDB; Q0P436; -.
DR   PRO; PR:Q0P436; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR   GO; GO:0006783; P:heme biosynthetic process; IMP:ZFIN.
DR   GO; GO:0070453; P:regulation of heme biosynthetic process; IBA:GO_Central.
DR   Gene3D; 1.10.10.1740; -; 1.
DR   InterPro; IPR005349; TMEM14.
DR   InterPro; IPR044890; TMEM14_sf.
DR   PANTHER; PTHR12668; PTHR12668; 1.
DR   Pfam; PF03647; Tmemb_14; 1.
PE   3: Inferred from homology;
KW   Heme biosynthesis; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..107
FT                   /note="Transmembrane protein 14C"
FT                   /id="PRO_0000386653"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   107 AA;  10681 MW;  DEC5FD3F63D85CD7 CRC64;
     MAVDWAGYGY AALVASGGVI GYVKAGSVPS LAAGLVFGGL AGFGAYQTSQ DPGNIWVSLA
     ASGTLAAIMG KRFYNSRKIT PAGLIAGASV LMLAKLGAGM LQKPQKS