TM14C_MOUSE
ID TM14C_MOUSE Reviewed; 114 AA.
AC Q9CQN6; Q543H6; Q9D849;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Transmembrane protein 14C;
GN Name=Tmem14c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Small intestine, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 62-80; 87-103 AND 104-114, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Lubec G., Kang S.U.;
RL Submitted (APR-2007) to UniProtKB.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for normal heme biosynthesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TMEM14 family. {ECO:0000305}.
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DR EMBL; AK003891; BAB23060.1; -; mRNA.
DR EMBL; AK008495; BAB25700.1; -; mRNA.
DR EMBL; AK008878; BAB25946.1; -; mRNA.
DR EMBL; AK010609; BAB27059.1; -; mRNA.
DR EMBL; AK012101; BAB28032.1; -; mRNA.
DR EMBL; AK019395; BAB31700.1; -; mRNA.
DR EMBL; AK050688; BAC34380.1; -; mRNA.
DR EMBL; BC025854; AAH25854.1; -; mRNA.
DR EMBL; BC055862; AAH55862.1; -; mRNA.
DR CCDS; CCDS26470.1; -.
DR RefSeq; NP_079663.1; NM_025387.3.
DR RefSeq; XP_006517000.2; XM_006516937.2.
DR RefSeq; XP_006517001.1; XM_006516938.3.
DR RefSeq; XP_006517002.1; XM_006516939.2.
DR AlphaFoldDB; Q9CQN6; -.
DR BioGRID; 211255; 2.
DR IntAct; Q9CQN6; 1.
DR STRING; 10090.ENSMUSP00000021790; -.
DR iPTMnet; Q9CQN6; -.
DR PhosphoSitePlus; Q9CQN6; -.
DR EPD; Q9CQN6; -.
DR jPOST; Q9CQN6; -.
DR MaxQB; Q9CQN6; -.
DR PaxDb; Q9CQN6; -.
DR PeptideAtlas; Q9CQN6; -.
DR PRIDE; Q9CQN6; -.
DR ProteomicsDB; 259462; -.
DR TopDownProteomics; Q9CQN6; -.
DR DNASU; 66154; -.
DR Ensembl; ENSMUST00000021790; ENSMUSP00000021790; ENSMUSG00000021361.
DR GeneID; 66154; -.
DR KEGG; mmu:66154; -.
DR UCSC; uc007qet.2; mouse.
DR CTD; 51522; -.
DR MGI; MGI:1913404; Tmem14c.
DR VEuPathDB; HostDB:ENSMUSG00000021361; -.
DR eggNOG; KOG4267; Eukaryota.
DR GeneTree; ENSGT00940000154772; -.
DR HOGENOM; CLU_096652_4_0_1; -.
DR InParanoid; Q9CQN6; -.
DR OMA; TYNRYLM; -.
DR OrthoDB; 1642026at2759; -.
DR PhylomeDB; Q9CQN6; -.
DR TreeFam; TF323345; -.
DR BioGRID-ORCS; 66154; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Tmem14c; mouse.
DR PRO; PR:Q9CQN6; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9CQN6; protein.
DR Bgee; ENSMUSG00000021361; Expressed in fetal liver hematopoietic progenitor cell and 328 other tissues.
DR Genevisible; Q9CQN6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
DR GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0030218; P:erythrocyte differentiation; IMP:MGI.
DR GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006839; P:mitochondrial transport; IMP:MGI.
DR GO; GO:0071705; P:nitrogen compound transport; IMP:MGI.
DR GO; GO:0071702; P:organic substance transport; IMP:MGI.
DR GO; GO:0070453; P:regulation of heme biosynthetic process; IMP:MGI.
DR Gene3D; 1.10.10.1740; -; 1.
DR InterPro; IPR005349; TMEM14.
DR InterPro; IPR044890; TMEM14_sf.
DR PANTHER; PTHR12668; PTHR12668; 1.
DR Pfam; PF03647; Tmemb_14; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme biosynthesis; Membrane; Mitochondrion;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..114
FT /note="Transmembrane protein 14C"
FT /id="PRO_0000221174"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 114 AA; 11642 MW; 709C784017F5D4B3 CRC64;
MQKDSGPLMP LHYFGFGYAA LVATGGIIGY AKAGSVPSLA AGLFFGGLAG LGAYQLSQDP
RNVWVFLATS GTLAGIMGMR FYNSGKFMPA GLIAGASLLM VAKVGISLLS SPHP
