ID   TM14C_PONAB             Reviewed;         112 AA.
AC   Q5R751;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Transmembrane protein 14C;
GN   Name=TMEM14C;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for normal heme biosynthesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM14 family. {ECO:0000305}.
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DR   EMBL; CR860267; CAH92409.1; -; mRNA.
DR   RefSeq; NP_001129017.1; NM_001135545.2.
DR   AlphaFoldDB; Q5R751; -.
DR   BMRB; Q5R751; -.
DR   Ensembl; ENSPPYT00000051444; ENSPPYP00000039464; ENSPPYG00000030032.
DR   GeneID; 100190858; -.
DR   KEGG; pon:100190858; -.
DR   CTD; 51522; -.
DR   GeneTree; ENSGT00940000154772; -.
DR   InParanoid; Q5R751; -.
DR   OrthoDB; 1642026at2759; -.
DR   Proteomes; UP000001595; Chromosome 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR   GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006839; P:mitochondrial transport; IEA:Ensembl.
DR   GO; GO:0071705; P:nitrogen compound transport; IEA:Ensembl.
DR   GO; GO:0071702; P:organic substance transport; IEA:Ensembl.
DR   GO; GO:0070453; P:regulation of heme biosynthetic process; IEA:Ensembl.
DR   Gene3D; 1.10.10.1740; -; 1.
DR   InterPro; IPR005349; TMEM14.
DR   InterPro; IPR044890; TMEM14_sf.
DR   PANTHER; PTHR12668; PTHR12668; 1.
DR   Pfam; PF03647; Tmemb_14; 1.
PE   3: Inferred from homology;
KW   Heme biosynthesis; Membrane; Mitochondrion; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..112
FT                   /note="Transmembrane protein 14C"
FT                   /id="PRO_0000328448"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   112 AA;  11567 MW;  6694A86082423913 CRC64;
     MQDTGSVVPL HWFGFGYAAL VASGGIIGYA KAGSVPSLAA GLLFGSLASL GAYQLSQDPR
     NVWVFLATSG TLAGIMGMRF YHSGKFMPAG LIAGASLLMV AKVGVSMFNR PH