ID   TM14C_RAT               Reviewed;         115 AA.
AC   Q924P2;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Transmembrane protein 14C;
DE   AltName: Full=p11;
GN   Name=Tmem14c; Synonyms=Cdtw1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar;
RA   Chopp M., Dou D., Tsang W., Wang L.;
RT   "Isolation of a novel gene up-regulated by stroke.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for normal heme biosynthesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM14 family. {ECO:0000305}.
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DR   EMBL; AF083396; AAK84687.1; -; mRNA.
DR   RefSeq; NP_599222.2; NM_134395.2.
DR   AlphaFoldDB; Q924P2; -.
DR   STRING; 10116.ENSRNOP00000020737; -.
DR   PhosphoSitePlus; Q924P2; -.
DR   PaxDb; Q924P2; -.
DR   PRIDE; Q924P2; -.
DR   GeneID; 171432; -.
DR   KEGG; rno:171432; -.
DR   UCSC; RGD:621692; rat.
DR   CTD; 51522; -.
DR   RGD; 621692; Tmem14c.
DR   eggNOG; KOG4267; Eukaryota.
DR   InParanoid; Q924P2; -.
DR   PhylomeDB; Q924P2; -.
DR   PRO; PR:Q924P2; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD.
DR   GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR   GO; GO:0030218; P:erythrocyte differentiation; ISO:RGD.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006839; P:mitochondrial transport; ISO:RGD.
DR   GO; GO:0070453; P:regulation of heme biosynthetic process; ISO:RGD.
DR   Gene3D; 1.10.10.1740; -; 1.
DR   InterPro; IPR005349; TMEM14.
DR   InterPro; IPR044890; TMEM14_sf.
DR   PANTHER; PTHR12668; PTHR12668; 1.
DR   Pfam; PF03647; Tmemb_14; 1.
PE   3: Inferred from homology;
KW   Heme biosynthesis; Membrane; Mitochondrion; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..115
FT                   /note="Transmembrane protein 14C"
FT                   /id="PRO_0000221175"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   115 AA;  11776 MW;  6761C77ED520597B CRC64;
     MQKDSGPLVP LHYYGFGYAA LVATGGIIGY AKAGSVPSLA AGLFFGGLAG LGAYQLSQDP
     RNVWVFLATS GTLAGIMGMR FYNSGKFMPA GLIAGASLLM VAPGVAKIQE ITTMP