ID   TM14E_HUMAN             Reviewed;         125 AA.
AC   Q6UXP3;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Transmembrane protein 14EP;
GN   Name=TMEM14EP; Synonyms=TMEM14E; ORFNames=UNQ9344/PRO34067;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM14 family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AY358260; AAQ88627.1; -; mRNA.
DR   EMBL; CH471052; EAW78784.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6UXP3; -.
DR   STRING; 9606.ENSP00000386163; -.
DR   GlyGen; Q6UXP3; 1 site, 1 O-linked glycan (1 site).
DR   BioMuta; HGNC:34386; -.
DR   DMDM; 74738233; -.
DR   PaxDb; Q6UXP3; -.
DR   PeptideAtlas; Q6UXP3; -.
DR   PRIDE; Q6UXP3; -.
DR   UCSC; uc010hvo.4; human.
DR   GeneCards; TMEM14EP; -.
DR   HGNC; HGNC:34386; TMEM14EP.
DR   neXtProt; NX_Q6UXP3; -.
DR   PharmGKB; PA162405891; -.
DR   eggNOG; KOG4267; Eukaryota.
DR   HOGENOM; CLU_162780_0_0_1; -.
DR   InParanoid; Q6UXP3; -.
DR   PhylomeDB; Q6UXP3; -.
DR   PathwayCommons; Q6UXP3; -.
DR   Pharos; Q6UXP3; Tdark.
DR   PRO; PR:Q6UXP3; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q6UXP3; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR   GO; GO:0070453; P:regulation of heme biosynthetic process; IBA:GO_Central.
DR   Gene3D; 1.10.10.1740; -; 1.
DR   InterPro; IPR005349; TMEM14.
DR   InterPro; IPR044890; TMEM14_sf.
DR   PANTHER; PTHR12668; PTHR12668; 1.
DR   Pfam; PF03647; Tmemb_14; 1.
PE   5: Uncertain;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..125
FT                   /note="Transmembrane protein 14EP"
FT                   /id="PRO_0000348435"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         82
FT                   /note="L -> P (in dbSNP:rs13077912)"
FT                   /id="VAR_046161"
SQ   SEQUENCE   125 AA;  13608 MW;  B341C0F9501B65CE CRC64;
     MQMDPGPQVP LYWLGFVYAA LAALGGISGY AKVGSVQSPS AGFFFSELAG LDASQPSRNP
     KEHLSSPVYI WDLARYYANK ILTLWNIYAC GFSCRCLLIV SKLGSMYGEQ ILSVVAMSQL
     GLMKN