TM154_HUMAN
ID TM154_HUMAN Reviewed; 183 AA.
AC Q6P9G4; Q8WUT7; Q96MQ8;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Transmembrane protein 154;
DE Flags: Precursor;
GN Name=TMEM154;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PHE-93.
RC TISSUE=Kidney, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q6P9G4; O14569: CYB561D2; NbExp=3; IntAct=EBI-13329239, EBI-717654;
CC Q6P9G4; Q9BWH2: FUNDC2; NbExp=3; IntAct=EBI-13329239, EBI-714482;
CC Q6P9G4; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-13329239, EBI-713304;
CC Q6P9G4; O43681: GET3; NbExp=3; IntAct=EBI-13329239, EBI-2515857;
CC Q6P9G4; P02724: GYPA; NbExp=3; IntAct=EBI-13329239, EBI-702665;
CC Q6P9G4; P30301: MIP; NbExp=3; IntAct=EBI-13329239, EBI-8449636;
CC Q6P9G4; Q59EV6: PPGB; NbExp=3; IntAct=EBI-13329239, EBI-14210385;
CC Q6P9G4; O43765: SGTA; NbExp=3; IntAct=EBI-13329239, EBI-347996;
CC Q6P9G4; Q96G79: SLC35A4; NbExp=3; IntAct=EBI-13329239, EBI-12363689;
CC Q6P9G4; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-13329239, EBI-12188413;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AK056590; BAB71226.1; -; mRNA.
DR EMBL; BC019600; AAH19600.1; -; mRNA.
DR EMBL; BC060775; AAH60775.1; -; mRNA.
DR CCDS; CCDS3779.1; -.
DR RefSeq; NP_689893.1; NM_152680.2.
DR AlphaFoldDB; Q6P9G4; -.
DR BioGRID; 128404; 40.
DR IntAct; Q6P9G4; 10.
DR STRING; 9606.ENSP00000302144; -.
DR iPTMnet; Q6P9G4; -.
DR PhosphoSitePlus; Q6P9G4; -.
DR BioMuta; TMEM154; -.
DR DMDM; 145566965; -.
DR EPD; Q6P9G4; -.
DR jPOST; Q6P9G4; -.
DR MassIVE; Q6P9G4; -.
DR PaxDb; Q6P9G4; -.
DR PeptideAtlas; Q6P9G4; -.
DR PRIDE; Q6P9G4; -.
DR ProteomicsDB; 67045; -.
DR Antibodypedia; 67855; 44 antibodies from 14 providers.
DR DNASU; 201799; -.
DR Ensembl; ENST00000304385.8; ENSP00000302144.3; ENSG00000170006.12.
DR GeneID; 201799; -.
DR KEGG; hsa:201799; -.
DR MANE-Select; ENST00000304385.8; ENSP00000302144.3; NM_152680.3; NP_689893.1.
DR UCSC; uc003imw.3; human.
DR CTD; 201799; -.
DR DisGeNET; 201799; -.
DR GeneCards; TMEM154; -.
DR HGNC; HGNC:26489; TMEM154.
DR HPA; ENSG00000170006; Tissue enhanced (esophagus, skin).
DR neXtProt; NX_Q6P9G4; -.
DR OpenTargets; ENSG00000170006; -.
DR PharmGKB; PA145007430; -.
DR VEuPathDB; HostDB:ENSG00000170006; -.
DR eggNOG; ENOG502SASK; Eukaryota.
DR GeneTree; ENSGT00390000016183; -.
DR InParanoid; Q6P9G4; -.
DR OMA; MNRSADC; -.
DR OrthoDB; 1505523at2759; -.
DR PhylomeDB; Q6P9G4; -.
DR TreeFam; TF336891; -.
DR PathwayCommons; Q6P9G4; -.
DR SignaLink; Q6P9G4; -.
DR BioGRID-ORCS; 201799; 13 hits in 1073 CRISPR screens.
DR ChiTaRS; TMEM154; human.
DR GenomeRNAi; 201799; -.
DR Pharos; Q6P9G4; Tdark.
DR PRO; PR:Q6P9G4; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q6P9G4; protein.
DR Bgee; ENSG00000170006; Expressed in upper arm skin and 144 other tissues.
DR ExpressionAtlas; Q6P9G4; baseline and differential.
DR Genevisible; Q6P9G4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028064; TMEM154.
DR Pfam; PF15102; TMEM154; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..183
FT /note="Transmembrane protein 154"
FT /id="PRO_0000284503"
FT TOPO_DOM 23..75
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..183
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 163..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 179
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C4Q9"
FT VARIANT 93
FT /note="S -> F (in dbSNP:rs17855714)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031755"
SQ SEQUENCE 183 AA; 20498 MW; 0C7BEF6131D7D5E1 CRC64;
MQAPRAALVF ALVIALVPVG RGNYEELENS GDTTVESERP NKVTIPSTFA AVTIKETLNA
NINSTNFAPD ENQLEFILMV LIPLILLVLL LLSVVFLATY YKRKRTKQEP SSQGSQSALQ
TYELGSENVK VPIFEEDTPS VMEIEMEELD KWMNSMNRNA DFECLPTLKE EKESNHNPSD
SES
