TM156_HUMAN
ID TM156_HUMAN Reviewed; 296 AA.
AC Q8N614; Q9H5N9;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Transmembrane protein 156;
GN Name=TMEM156;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Smooth muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-105.
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK026888; BAB15583.1; -; mRNA.
DR EMBL; BC030803; AAH30803.1; -; mRNA.
DR CCDS; CCDS3448.1; -.
DR RefSeq; NP_001290157.1; NM_001303228.1.
DR RefSeq; NP_079219.1; NM_024943.2.
DR RefSeq; XP_011512051.1; XM_011513749.2.
DR AlphaFoldDB; Q8N614; -.
DR BioGRID; 123065; 5.
DR IntAct; Q8N614; 3.
DR STRING; 9606.ENSP00000371364; -.
DR GlyGen; Q8N614; 4 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q8N614; -.
DR PhosphoSitePlus; Q8N614; -.
DR BioMuta; TMEM156; -.
DR DMDM; 145566966; -.
DR MassIVE; Q8N614; -.
DR PaxDb; Q8N614; -.
DR PeptideAtlas; Q8N614; -.
DR PRIDE; Q8N614; -.
DR ProteomicsDB; 72125; -.
DR Antibodypedia; 23382; 7 antibodies from 5 providers.
DR DNASU; 80008; -.
DR Ensembl; ENST00000381938.4; ENSP00000371364.3; ENSG00000121895.8.
DR GeneID; 80008; -.
DR KEGG; hsa:80008; -.
DR MANE-Select; ENST00000381938.4; ENSP00000371364.3; NM_024943.3; NP_079219.1.
DR UCSC; uc003gto.4; human.
DR CTD; 80008; -.
DR DisGeNET; 80008; -.
DR GeneCards; TMEM156; -.
DR HGNC; HGNC:26260; TMEM156.
DR HPA; ENSG00000121895; Tissue enriched (lymphoid).
DR neXtProt; NX_Q8N614; -.
DR OpenTargets; ENSG00000121895; -.
DR PharmGKB; PA145007464; -.
DR VEuPathDB; HostDB:ENSG00000121895; -.
DR eggNOG; ENOG502SAF3; Eukaryota.
DR GeneTree; ENSGT00390000017929; -.
DR HOGENOM; CLU_081882_0_0_1; -.
DR InParanoid; Q8N614; -.
DR OMA; GKSINHT; -.
DR OrthoDB; 1271265at2759; -.
DR PhylomeDB; Q8N614; -.
DR TreeFam; TF336964; -.
DR PathwayCommons; Q8N614; -.
DR SignaLink; Q8N614; -.
DR BioGRID-ORCS; 80008; 7 hits in 1076 CRISPR screens.
DR ChiTaRS; TMEM156; human.
DR GenomeRNAi; 80008; -.
DR Pharos; Q8N614; Tdark.
DR PRO; PR:Q8N614; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8N614; protein.
DR Bgee; ENSG00000121895; Expressed in buccal mucosa cell and 119 other tissues.
DR ExpressionAtlas; Q8N614; baseline and differential.
DR Genevisible; Q8N614; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029374; TMEM156.
DR PANTHER; PTHR14788; PTHR14788; 1.
DR Pfam; PF15106; TMEM156; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..296
FT /note="Transmembrane protein 156"
FT /id="PRO_0000284505"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..296
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 48
FT /note="Y -> C (in dbSNP:rs35576563)"
FT /id="VAR_031756"
FT VARIANT 105
FT /note="S -> P (in dbSNP:rs11542133)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_051430"
FT VARIANT 212
FT /note="M -> T (in dbSNP:rs2276887)"
FT /id="VAR_031757"
SQ SEQUENCE 296 AA; 34323 MW; 54DE078ECC1BCE97 CRC64;
MTKTALLKLF VAIVITFILI LPEYFKTPKE RTLELSCLEV CLQSNFTYSL SSLNFSFVTF
LQPVRETQII MRIFLNPSNF RNFTRTCQDI TGEFKMCSSC LVCESKGNMD FISQEQTSKV
LIRRGSMEVK ANDFHSPCQH FNFSVAPLVD HLEEYNTTCH LKNHTGRSTI MEDEPSKEKS
INYTCRIMEY PNDCIHISLH LEMDIKNITC SMKITWYILV LLVFIFLIIL TIRKILEGQR
RVQKWQSHRD KPTSVLLRGS DSEKLRALNV QVLSAETTQR LPLDQVQEVL PPIPEL
