ID   TM158_BOVIN             Reviewed;         291 AA.
AC   A2VDX9;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Transmembrane protein 158;
DE   AltName: Full=Ras-induced senescence protein 1;
DE   Flags: Precursor;
GN   Name=TMEM158; Synonyms=RIS1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for brain injury-derived neurotrophic peptide
CC       (BINP), a synthetic 13-mer peptide. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: N-glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM158 family. {ECO:0000305}.
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DR   EMBL; BC133460; AAI33461.1; -; mRNA.
DR   RefSeq; NP_001075095.1; NM_001081626.1.
DR   AlphaFoldDB; A2VDX9; -.
DR   SMR; A2VDX9; -.
DR   STRING; 9913.ENSBTAP00000041835; -.
DR   PaxDb; A2VDX9; -.
DR   Ensembl; ENSBTAT00000044329; ENSBTAP00000041835; ENSBTAG00000031287.
DR   GeneID; 788085; -.
DR   KEGG; bta:788085; -.
DR   CTD; 25907; -.
DR   VEuPathDB; HostDB:ENSBTAG00000031287; -.
DR   VGNC; VGNC:99741; TMEM158.
DR   eggNOG; ENOG502RYJ7; Eukaryota.
DR   GeneTree; ENSGT00390000009719; -.
DR   HOGENOM; CLU_085099_0_0_1; -.
DR   InParanoid; A2VDX9; -.
DR   OMA; RLHFCCL; -.
DR   OrthoDB; 1276094at2759; -.
DR   TreeFam; TF339241; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000031287; Expressed in myometrium and 96 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR   InterPro; IPR038962; TMEM158.
DR   PANTHER; PTHR38324; PTHR38324; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..291
FT                   /note="Transmembrane protein 158"
FT                   /id="PRO_0000285127"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        71
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   291 AA;  29638 MW;  ABF8BE8E5918A84B CRC64;
     MLPLLAALLA AACPLPPARG GAVDAPGLLG APLNASVNAS SSDEPAAPRL LASAAPGAPE
     RPEEEAAAPC NISVQRQMLS SLLVRWGRPR GFQCDLLLFS TNAHGRAFFA AAFHRVGPPL
     LIEHLGLAAG GAQQDLRLCV GCGWVRGRRP GRLRPTGATA GAPTALPAYP AAEPPGPLWL
     QGEPLHFCCL DFSLEELQGE PGWRLNRKPI ESTLVACFMT LVIVVWSVAA LIWPVPIIAG
     FLPNGMEQRR TTASAAAAAP AAVPAGTTAA AAAAAAAAAA AAAVTSGTAT K