TM158_HUMAN
ID TM158_HUMAN Reviewed; 300 AA.
AC Q8WZ71; Q6PFW5; Q9Y4M1;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Transmembrane protein 158;
DE AltName: Full=40 kDa BINP-binding protein;
DE Short=p40BBP;
DE AltName: Full=Ras-induced senescence protein 1;
DE Flags: Precursor;
GN Name=TMEM158; Synonyms=HBBP, RIS1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INDUCTION.
RX PubMed=11822868; DOI=10.1006/excr.2001.5434;
RA Barradas M., Gonos E.S., Zebedee Z., Kolettas E., Petropoulou C.,
RA Delgado M.D., Leon J., Hara E., Serrano M.;
RT "Identification of a candidate tumor-suppressor gene specifically activated
RT during Ras-induced senescence.";
RL Exp. Cell Res. 273:127-137(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Hippocampus;
RA Hama T.;
RT "Isolation of human homologue of rat p40BBp (brain specific binding
RT protein.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 151-300 (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: Receptor for brain injury-derived neurotrophic peptide
CC (BINP), a synthetic 13-mer peptide. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WZ71-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WZ71-2; Sequence=VSP_024826;
CC -!- INDUCTION: Up-regulated during Ras-induced senescence.
CC {ECO:0000269|PubMed:11822868}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TMEM158 family. {ECO:0000305}.
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DR EMBL; AF438313; AAL30845.1; -; mRNA.
DR EMBL; AB078417; BAC05687.1; -; mRNA.
DR EMBL; AC010170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057390; AAH57390.1; -; mRNA.
DR EMBL; AL080235; CAB45781.1; -; mRNA.
DR CCDS; CCDS54573.1; -. [Q8WZ71-1]
DR PIR; T12547; T12547.
DR RefSeq; NP_056259.2; NM_015444.2. [Q8WZ71-1]
DR AlphaFoldDB; Q8WZ71; -.
DR BioGRID; 117413; 2.
DR IntAct; Q8WZ71; 3.
DR MINT; Q8WZ71; -.
DR STRING; 9606.ENSP00000422431; -.
DR GlyGen; Q8WZ71; 1 site.
DR iPTMnet; Q8WZ71; -.
DR PhosphoSitePlus; Q8WZ71; -.
DR BioMuta; TMEM158; -.
DR DMDM; 408360199; -.
DR jPOST; Q8WZ71; -.
DR MassIVE; Q8WZ71; -.
DR PaxDb; Q8WZ71; -.
DR PeptideAtlas; Q8WZ71; -.
DR PRIDE; Q8WZ71; -.
DR ProteomicsDB; 75226; -. [Q8WZ71-1]
DR ProteomicsDB; 75227; -. [Q8WZ71-2]
DR Antibodypedia; 45715; 80 antibodies from 18 providers.
DR DNASU; 25907; -.
DR Ensembl; ENST00000503771.2; ENSP00000422431.1; ENSG00000249992.2. [Q8WZ71-1]
DR GeneID; 25907; -.
DR KEGG; hsa:25907; -.
DR MANE-Select; ENST00000503771.2; ENSP00000422431.1; NM_015444.3; NP_056259.2.
DR UCSC; uc011baf.3; human. [Q8WZ71-1]
DR CTD; 25907; -.
DR DisGeNET; 25907; -.
DR GeneCards; TMEM158; -.
DR HGNC; HGNC:30293; TMEM158.
DR HPA; ENSG00000249992; Tissue enhanced (brain, endometrium).
DR neXtProt; NX_Q8WZ71; -.
DR OpenTargets; ENSG00000249992; -.
DR PharmGKB; PA128395777; -.
DR VEuPathDB; HostDB:ENSG00000249992; -.
DR eggNOG; ENOG502RYJ7; Eukaryota.
DR GeneTree; ENSGT00390000009719; -.
DR HOGENOM; CLU_085099_0_0_1; -.
DR InParanoid; Q8WZ71; -.
DR OMA; RLHFCCL; -.
DR OrthoDB; 1276094at2759; -.
DR PhylomeDB; Q8WZ71; -.
DR TreeFam; TF339241; -.
DR PathwayCommons; Q8WZ71; -.
DR SignaLink; Q8WZ71; -.
DR BioGRID-ORCS; 25907; 12 hits in 1082 CRISPR screens.
DR ChiTaRS; TMEM158; human.
DR GeneWiki; TMEM158; -.
DR GenomeRNAi; 25907; -.
DR Pharos; Q8WZ71; Tbio.
DR PRO; PR:Q8WZ71; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8WZ71; protein.
DR Bgee; ENSG00000249992; Expressed in seminal vesicle and 149 other tissues.
DR Genevisible; Q8WZ71; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR InterPro; IPR038962; TMEM158.
DR PANTHER; PTHR38324; PTHR38324; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..300
FT /note="Transmembrane protein 158"
FT /id="PRO_0000285128"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 273..286
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024826"
FT CONFLICT 67
FT /note="A -> T (in Ref. 1; AAL30845 and 2; BAC05687)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 300 AA; 30404 MW; A555CC499B7FE0DC CRC64;
MLPLLAALLA AACPLPPVRG GAADAPGLLG VPSNASVNAS SADEPIAPRL LASAAPGPPE
RPGPEEAAAA AAPCNISVQR QMLSSLLVRW GRPRGFQCDL LLFSTNAHGR AFFAAAFHRV
GPPLLIEHLG LAAGGAQQDL RLCVGCGWVR GRRTGRLRPA AAPSAAAATA GAPTALPAYP
AAEPPGPLWL QGEPLHFCCL DFSLEELQGE PGWRLNRKPI ESTLVACFMT LVIVVWSVAA
LIWPVPIIAG FLPNGMEQRR TTASTTAATP AAVPAGTTAA AAAAAAAAAA AAVTSGVATK
