ID   TM158_RAT               Reviewed;         285 AA.
AC   Q91XV7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Transmembrane protein 158;
DE   AltName: Full=40 kDa BINP-binding protein;
DE            Short=p40BBP;
DE   AltName: Full=Brain-specific binding protein;
DE   AltName: Full=Ras-induced senescence protein 1;
DE   Flags: Precursor;
GN   Name=Tmem158; Synonyms=Ris1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND
RP   GLYCOSYLATION.
RC   TISSUE=Hippocampus;
RX   PubMed=11399754; DOI=10.1074/jbc.m100617200;
RA   Hama T., Maruyama M., Katoh-Semba R., Takizawa M., Iwashima M., Nara K.;
RT   "Identification and molecular cloning of a novel brain-specific receptor
RT   protein that binds to brain injury-derived neurotrophic peptide. Possible
RT   role for neuronal survival.";
RL   J. Biol. Chem. 276:31929-31935(2001).
CC   -!- FUNCTION: Receptor for brain injury-derived neurotrophic peptide
CC       (BINP), a synthetic 13-mer peptide. {ECO:0000250,
CC       ECO:0000269|PubMed:11399754}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Detected only in the brain.
CC       {ECO:0000269|PubMed:11399754}.
CC   -!- PTM: N-glycosylated. {ECO:0000269|PubMed:11399754}.
CC   -!- SIMILARITY: Belongs to the TMEM158 family. {ECO:0000305}.
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DR   EMBL; AB028891; BAB63459.1; -; mRNA.
DR   RefSeq; NP_476560.1; NM_057212.1.
DR   AlphaFoldDB; Q91XV7; -.
DR   STRING; 10116.ENSRNOP00000006300; -.
DR   GlyGen; Q91XV7; 1 site.
DR   PhosphoSitePlus; Q91XV7; -.
DR   jPOST; Q91XV7; -.
DR   PaxDb; Q91XV7; -.
DR   Ensembl; ENSRNOT00000006300; ENSRNOP00000006300; ENSRNOG00000004757.
DR   GeneID; 117582; -.
DR   KEGG; rno:117582; -.
DR   UCSC; RGD:708473; rat.
DR   CTD; 25907; -.
DR   RGD; 708473; Tmem158.
DR   eggNOG; ENOG502RYJ7; Eukaryota.
DR   GeneTree; ENSGT00390000009719; -.
DR   HOGENOM; CLU_085099_0_0_1; -.
DR   InParanoid; Q91XV7; -.
DR   OMA; RLHFCCL; -.
DR   OrthoDB; 1276094at2759; -.
DR   PhylomeDB; Q91XV7; -.
DR   TreeFam; TF339241; -.
DR   PRO; PR:Q91XV7; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000004757; Expressed in frontal cortex and 17 other tissues.
DR   Genevisible; Q91XV7; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042277; F:peptide binding; IMP:RGD.
DR   GO; GO:0038023; F:signaling receptor activity; TAS:RGD.
DR   InterPro; IPR038962; TMEM158.
DR   PANTHER; PTHR38324; PTHR38324; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..285
FT                   /note="Transmembrane protein 158"
FT                   /id="PRO_0000285130"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          20..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        73
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   285 AA;  29005 MW;  E1815ED358A07AF7 CRC64;
     MLPLLAALLA AACPLPPARG GATDAPGLSG TPPNASANAS FTGEHSTPRL LASAASAPPE
     RAGPEEAPAA PCNISVQRQM LSSLLVRWGR PRGLQCDLLL FSTNAHGRAF FAAAFHRVGP
     PLLIEHLGLA AGGAQQDLRL CVGCGWVRGR LRAPAGAPTA LPAYPAAEPG PLWLQGEPRH
     FCCLDFSLEE LQGEPGWRLN RKPIESTLVA CFMTLVIVVW SVAALIWPVP IIAGFLPNGM
     EQRRTTAGAP AAAPAAVPAG TTAAAAAAAA AAAAAAAVTS GVAPK