TM160_HUMAN
ID TM160_HUMAN Reviewed; 188 AA.
AC Q9NX00; Q9BU41;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Transmembrane protein 160;
GN Name=TMEM160;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-120.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- INTERACTION:
CC Q9NX00; P54849: EMP1; NbExp=3; IntAct=EBI-2514588, EBI-4319440;
CC Q9NX00; Q7RTY0: SLC16A13; NbExp=3; IntAct=EBI-2514588, EBI-12243266;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM160 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK000519; BAA91225.1; -; mRNA.
DR EMBL; BC002907; AAH02907.1; -; mRNA.
DR CCDS; CCDS12695.1; -.
DR RefSeq; NP_060324.1; NM_017854.1.
DR AlphaFoldDB; Q9NX00; -.
DR BioGRID; 120296; 105.
DR IntAct; Q9NX00; 24.
DR MINT; Q9NX00; -.
DR STRING; 9606.ENSP00000253047; -.
DR TCDB; 8.A.184.1.1; the transmembrane protein tmem160 (tmem160) family.
DR iPTMnet; Q9NX00; -.
DR PhosphoSitePlus; Q9NX00; -.
DR SwissPalm; Q9NX00; -.
DR BioMuta; TMEM160; -.
DR DMDM; 74719401; -.
DR EPD; Q9NX00; -.
DR jPOST; Q9NX00; -.
DR MassIVE; Q9NX00; -.
DR MaxQB; Q9NX00; -.
DR PaxDb; Q9NX00; -.
DR PeptideAtlas; Q9NX00; -.
DR PRIDE; Q9NX00; -.
DR ProteomicsDB; 83007; -.
DR TopDownProteomics; Q9NX00; -.
DR Antibodypedia; 65063; 14 antibodies from 12 providers.
DR DNASU; 54958; -.
DR Ensembl; ENST00000253047.7; ENSP00000253047.5; ENSG00000130748.7.
DR GeneID; 54958; -.
DR KEGG; hsa:54958; -.
DR MANE-Select; ENST00000253047.7; ENSP00000253047.5; NM_017854.2; NP_060324.1.
DR UCSC; uc002pfz.4; human.
DR CTD; 54958; -.
DR DisGeNET; 54958; -.
DR GeneCards; TMEM160; -.
DR HGNC; HGNC:26042; TMEM160.
DR HPA; ENSG00000130748; Low tissue specificity.
DR neXtProt; NX_Q9NX00; -.
DR OpenTargets; ENSG00000130748; -.
DR PharmGKB; PA145147949; -.
DR VEuPathDB; HostDB:ENSG00000130748; -.
DR eggNOG; ENOG502S3E7; Eukaryota.
DR GeneTree; ENSGT00390000012863; -.
DR HOGENOM; CLU_110295_0_0_1; -.
DR InParanoid; Q9NX00; -.
DR OMA; GCNLPEA; -.
DR OrthoDB; 1344928at2759; -.
DR PhylomeDB; Q9NX00; -.
DR TreeFam; TF338764; -.
DR PathwayCommons; Q9NX00; -.
DR SignaLink; Q9NX00; -.
DR BioGRID-ORCS; 54958; 15 hits in 1078 CRISPR screens.
DR GenomeRNAi; 54958; -.
DR Pharos; Q9NX00; Tdark.
DR PRO; PR:Q9NX00; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9NX00; protein.
DR Bgee; ENSG00000130748; Expressed in amygdala and 167 other tissues.
DR Genevisible; Q9NX00; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026801; TMEM160.
DR PANTHER; PTHR16236; PTHR16236; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..188
FT /note="Transmembrane protein 160"
FT /id="PRO_0000277810"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 24..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 48
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 120
FT /note="G -> S (in dbSNP:rs11083857)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030600"
SQ SEQUENCE 188 AA; 19658 MW; 955BE1A693B46A28 CRC64;
MGGGWWWARA ARLARLRFRR SLLPPQRPRS GGARGSFAPG HGPRAGASPP PVSELDRADA
WLLRKAHETA FLSWFRNGLL ASGIGVISFM QSDMGREAAY GFFLLGGLCV VWGSASYAVG
LAALRGPMQL TLGGAAVGAG AVLAASLLWA CAVGLYMGQL ELDVELVPED DGTASAEGPD
EAGRPPPE
