TM163_BOVIN
ID TM163_BOVIN Reviewed; 287 AA.
AC A6QQX9;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Transmembrane protein 163;
GN Name=TMEM163;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal pons;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May bind zinc and other divalent cations and recruit them to
CC vesicular organelles. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Early endosome membrane {ECO:0000250}.
CC Note=Glutamatergic synaptic vesicles. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TMEM163 family. {ECO:0000305}.
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DR EMBL; DAAA02005010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DAAA02005011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DAAA02005012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DAAA02005013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC150036; AAI50037.1; -; mRNA.
DR RefSeq; NP_001094630.1; NM_001101160.2.
DR AlphaFoldDB; A6QQX9; -.
DR SMR; A6QQX9; -.
DR STRING; 9913.ENSBTAP00000024972; -.
DR PaxDb; A6QQX9; -.
DR Ensembl; ENSBTAT00000024972; ENSBTAP00000024972; ENSBTAG00000018753.
DR GeneID; 534678; -.
DR KEGG; bta:534678; -.
DR CTD; 81615; -.
DR VEuPathDB; HostDB:ENSBTAG00000018753; -.
DR VGNC; VGNC:35988; TMEM163.
DR eggNOG; ENOG502QW7B; Eukaryota.
DR GeneTree; ENSGT00390000001170; -.
DR HOGENOM; CLU_081161_0_0_1; -.
DR InParanoid; A6QQX9; -.
DR OMA; IMRYSAS; -.
DR OrthoDB; 1547703at2759; -.
DR TreeFam; TF330782; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000018753; Expressed in oocyte and 92 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR GO; GO:0030285; C:integral component of synaptic vesicle membrane; ISS:UniProtKB.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR Gene3D; 1.20.1510.10; -; 1.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR026765; Tmem163.
DR PANTHER; PTHR31937; PTHR31937; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; Endosome; Membrane; Phosphoprotein;
KW Reference proteome; Synapse; Transmembrane; Transmembrane helix; Zinc.
FT CHAIN 1..287
FT /note="Transmembrane protein 163"
FT /id="PRO_0000416585"
FT TOPO_DOM 1..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..114
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..215
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 237..253
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 11
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A9CMA6"
FT MOD_RES 53
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C996"
FT MOD_RES 55
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C996"
FT MOD_RES 59
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C996"
SQ SEQUENCE 287 AA; 31195 MW; EAD2C67C49265712 CRC64;
METAAGSERR STPGPAVPPP PRGHAPLATA SGPLSSPARE PPQPEEERQL RISESGQFSD
GLEDRGLLES STRLKPHEAQ NYRKKALWVS WFSIIVTLAL AVAAFTVSVM RYSASAFGFA
FDAILDVLSS AIVLWRYSNA AAVHSAHREY IACVILGVIF LLSSVCIVVK AIHDLSTKLL
PEVDDFLFSV SILSGILCSI LAVLKFMLGK VLTSRALITD GFNSLVGGVM GFSILLSAEV
FKHNSAVWYL DGSIGVLIGL TIFAYGVKLL IDMVPRVRQT RHYEMFE
