ID   TM163_XENLA             Reviewed;         281 AA.
AC   Q6GLN7;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Transmembrane protein 163;
GN   Name=tmem163;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May bind zinc and other divalent cations and recruit them to
CC       vesicular organelles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC       vesicle membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Early endosome membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM163 family. {ECO:0000305}.
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DR   EMBL; BC074423; AAH74423.1; -; mRNA.
DR   RefSeq; NP_001086283.1; NM_001092814.1.
DR   AlphaFoldDB; Q6GLN7; -.
DR   SMR; Q6GLN7; -.
DR   DNASU; 444712; -.
DR   GeneID; 444712; -.
DR   KEGG; xla:444712; -.
DR   CTD; 444712; -.
DR   Xenbase; XB-GENE-5808429; tmem163.L.
DR   OMA; IMRYSAS; -.
DR   OrthoDB; 1547703at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 444712; Expressed in brain and 6 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR   GO; GO:0030285; C:integral component of synaptic vesicle membrane; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   InterPro; IPR026765; Tmem163.
DR   PANTHER; PTHR31937; PTHR31937; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Endosome; Membrane; Reference proteome; Synapse;
KW   Transmembrane; Transmembrane helix; Zinc.
FT   CHAIN           1..281
FT                   /note="Transmembrane protein 163"
FT                   /id="PRO_0000278541"
FT   TOPO_DOM        1..80
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..108
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..145
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        167..179
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..209
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        231..240
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        262..281
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          16..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   281 AA;  31056 MW;  BA946CD01DE803D7 CRC64;
     MEPLDTELCY DPDPSIVQPS CNGQTPPGHR TLSPTQQMDH EQQMKISESG QFSDVVENRG
     LLESSTRLKP HEAQNYRKKA LWVSWLSIAI TLILAIAAFT VSVMRYSASS FGFALDAVLD
     VLSSAIVLWR YSNAAAVHSA HREYMACCIL GVIFLLSSIC IVSKAIHDLS IRVMPEVDGF
     LFSVSILSGI LCSLLAAIKF MLGKVLTSRA LITDGFNSLV GGIMGFSILL SAEVYKHNSK
     VWYLDGSVGI LIGLIIMSYG IKLLMDMVPR VRQTRHYEMF E