TM164_HUMAN
ID TM164_HUMAN Reviewed; 297 AA.
AC Q5U3C3; B3KSQ8; F5H2P2;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Transmembrane protein 164;
GN Name=TMEM164;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP VARIANT [LARGE SCALE ANALYSIS] HIS-276.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5U3C3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5U3C3-2; Sequence=VSP_044964;
CC -!- SIMILARITY: Belongs to the TMEM164 family. {ECO:0000305}.
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DR EMBL; AK094127; BAG52820.1; -; mRNA.
DR EMBL; AL360224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL359079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC085605; AAH85605.1; -; mRNA.
DR CCDS; CCDS14550.2; -. [Q5U3C3-1]
DR CCDS; CCDS55475.1; -. [Q5U3C3-2]
DR RefSeq; NP_060168.2; NM_017698.2. [Q5U3C3-2]
DR RefSeq; NP_115603.2; NM_032227.3. [Q5U3C3-1]
DR RefSeq; XP_005262262.1; XM_005262205.4. [Q5U3C3-1]
DR RefSeq; XP_005262263.1; XM_005262206.3.
DR RefSeq; XP_011529356.1; XM_011531054.1. [Q5U3C3-2]
DR RefSeq; XP_011529357.1; XM_011531055.2. [Q5U3C3-2]
DR AlphaFoldDB; Q5U3C3; -.
DR BioGRID; 123935; 36.
DR IntAct; Q5U3C3; 16.
DR STRING; 9606.ENSP00000361143; -.
DR iPTMnet; Q5U3C3; -.
DR PhosphoSitePlus; Q5U3C3; -.
DR SwissPalm; Q5U3C3; -.
DR BioMuta; TMEM164; -.
DR DMDM; 74746752; -.
DR EPD; Q5U3C3; -.
DR jPOST; Q5U3C3; -.
DR MassIVE; Q5U3C3; -.
DR MaxQB; Q5U3C3; -.
DR PaxDb; Q5U3C3; -.
DR PeptideAtlas; Q5U3C3; -.
DR PRIDE; Q5U3C3; -.
DR ProteomicsDB; 26029; -.
DR ProteomicsDB; 65224; -. [Q5U3C3-1]
DR Antibodypedia; 51401; 24 antibodies from 12 providers.
DR DNASU; 84187; -.
DR Ensembl; ENST00000372068.7; ENSP00000361138.2; ENSG00000157600.12. [Q5U3C3-1]
DR Ensembl; ENST00000372072.7; ENSP00000384075.2; ENSG00000157600.12. [Q5U3C3-2]
DR Ensembl; ENST00000372073.5; ENSP00000361143.1; ENSG00000157600.12. [Q5U3C3-1]
DR GeneID; 84187; -.
DR KEGG; hsa:84187; -.
DR MANE-Select; ENST00000372068.7; ENSP00000361138.2; NM_032227.4; NP_115603.2.
DR UCSC; uc004eom.4; human. [Q5U3C3-1]
DR CTD; 84187; -.
DR DisGeNET; 84187; -.
DR GeneCards; TMEM164; -.
DR HGNC; HGNC:26217; TMEM164.
DR HPA; ENSG00000157600; Low tissue specificity.
DR neXtProt; NX_Q5U3C3; -.
DR OpenTargets; ENSG00000157600; -.
DR PharmGKB; PA145148045; -.
DR VEuPathDB; HostDB:ENSG00000157600; -.
DR eggNOG; ENOG502QWAJ; Eukaryota.
DR GeneTree; ENSGT00390000007430; -.
DR HOGENOM; CLU_133892_0_0_1; -.
DR InParanoid; Q5U3C3; -.
DR OMA; IPRNVGP; -.
DR OrthoDB; 1509337at2759; -.
DR PhylomeDB; Q5U3C3; -.
DR TreeFam; TF324458; -.
DR PathwayCommons; Q5U3C3; -.
DR SignaLink; Q5U3C3; -.
DR BioGRID-ORCS; 84187; 25 hits in 712 CRISPR screens.
DR ChiTaRS; TMEM164; human.
DR GenomeRNAi; 84187; -.
DR Pharos; Q5U3C3; Tdark.
DR PRO; PR:Q5U3C3; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5U3C3; protein.
DR Bgee; ENSG00000157600; Expressed in ileal mucosa and 206 other tissues.
DR ExpressionAtlas; Q5U3C3; baseline and differential.
DR Genevisible; Q5U3C3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026508; TMEM164.
DR PANTHER; PTHR20948; PTHR20948; 1.
DR Pfam; PF14808; TMEM164; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..297
FT /note="Transmembrane protein 164"
FT /id="PRO_0000259640"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 65..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..149
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044964"
FT VARIANT 204
FT /note="S -> N (in dbSNP:rs34026111)"
FT /id="VAR_054035"
FT VARIANT 276
FT /note="Y -> H (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035671"
FT CONFLICT 227
FT /note="L -> F (in Ref. 1; BAG52820)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 297 AA; 33508 MW; A4E3D055CF4FF8C3 CRC64;
MSRYSYQSLL DWLYGGVDPS FAGNGGPDCA AFLSWQQRLL ESVVVLTLAL LEILVALRHI
LRQTKEDGRG SPGSQPEQVT QRPEEGKESL SKNLLLVALC LTFGVEVGFK FATKTVIYLL
NPCHLVTMMH IFLLACPPCR GAIVVFKLQM HMLNGALLAL LFPVVNTRLL PFELEIYYIQ
HVMLYVVPIY LLWKGGAYTP EPLSSFRWAL LSTGLMFFYH FSVLQILGLV TEVNLNNMLC
PAISDPFYGP WYRIWASGHQ TLMTMTHGKL VILFSYMAGP LCKYLLDLLR LPAKKID
