TM164_MOUSE
ID TM164_MOUSE Reviewed; 296 AA.
AC Q6PHN7;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Transmembrane protein 164;
GN Name=Tmem164;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM164 family. {ECO:0000305}.
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DR EMBL; AK165839; BAE38406.1; -; mRNA.
DR EMBL; AK165910; BAE38455.1; -; mRNA.
DR EMBL; BC056470; AAH56470.1; -; mRNA.
DR CCDS; CCDS30451.1; -.
DR RefSeq; NP_001186289.1; NM_001199360.1.
DR RefSeq; NP_808260.2; NM_177592.4.
DR AlphaFoldDB; Q6PHN7; -.
DR STRING; 10090.ENSMUSP00000108517; -.
DR iPTMnet; Q6PHN7; -.
DR PhosphoSitePlus; Q6PHN7; -.
DR MaxQB; Q6PHN7; -.
DR PaxDb; Q6PHN7; -.
DR PeptideAtlas; Q6PHN7; -.
DR PRIDE; Q6PHN7; -.
DR ProteomicsDB; 258905; -.
DR Antibodypedia; 51401; 24 antibodies from 12 providers.
DR Ensembl; ENSMUST00000087333; ENSMUSP00000084591; ENSMUSG00000047045.
DR Ensembl; ENSMUST00000112896; ENSMUSP00000108517; ENSMUSG00000047045.
DR Ensembl; ENSMUST00000133634; ENSMUSP00000138503; ENSMUSG00000047045.
DR GeneID; 209497; -.
DR KEGG; mmu:209497; -.
DR UCSC; uc009ulx.2; mouse.
DR CTD; 84187; -.
DR MGI; MGI:2148020; Tmem164.
DR VEuPathDB; HostDB:ENSMUSG00000047045; -.
DR eggNOG; ENOG502QWAJ; Eukaryota.
DR GeneTree; ENSGT00390000007430; -.
DR HOGENOM; CLU_072415_0_0_1; -.
DR InParanoid; Q6PHN7; -.
DR OMA; IPRNVGP; -.
DR OrthoDB; 1509337at2759; -.
DR PhylomeDB; Q6PHN7; -.
DR TreeFam; TF324458; -.
DR BioGRID-ORCS; 209497; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Tmem164; mouse.
DR PRO; PR:Q6PHN7; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q6PHN7; protein.
DR Bgee; ENSMUSG00000047045; Expressed in paneth cell and 227 other tissues.
DR ExpressionAtlas; Q6PHN7; baseline and differential.
DR Genevisible; Q6PHN7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026508; TMEM164.
DR PANTHER; PTHR20948; PTHR20948; 1.
DR Pfam; PF14808; TMEM164; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..296
FT /note="Transmembrane protein 164"
FT /id="PRO_0000259641"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 66..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 296 AA; 33441 MW; 9240EBD6F9F231A9 CRC64;
MSRYSYQSLL DWLYGGVDPS FAGNGGPDCA AFLSWQQRLL ESVVVLTLAL LEILVALRHI
LRQKEDGRGG RSSQPQQVTQ RPEEGKESLS KNLLLVALCL IFGVEVGFKF ATKTVIYLLN
PCHLVTMMHI FLLACPPCPG ATVIFKLQMH MLNGALLALL FPVVNTRLLP FELEIYYIQH
AMLYVVPVYL LWKGGAYTPE PLCNFQWALL STGLMFFYHF SFLQILGLVT EVNLNNMLCP
AISDPFYGPW YRIWASGHQT LMTMTHGKLV ILFSYMAGPL CKYLLDLLRL PAKKID
