TM165_RAT
ID TM165_RAT Reviewed; 323 AA.
AC Q4V899;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Transmembrane protein 165;
DE AltName: Full=Transmembrane protein TPARL;
DE Flags: Precursor;
GN Name=Tmem165; Synonyms=Tparl;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May function as a calcium/proton transporter involved in
CC calcium and in lysosomal pH homeostasis. Therefore, it may play an
CC indirect role in protein glycosylation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi
CC network membrane {ECO:0000250}. Lysosome membrane {ECO:0000250}. Early
CC endosome membrane {ECO:0000250}. Late endosome membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GDT1 family. {ECO:0000305}.
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DR EMBL; BC097478; AAH97478.1; -; mRNA.
DR RefSeq; NP_001019973.1; NM_001024802.1.
DR AlphaFoldDB; Q4V899; -.
DR STRING; 10116.ENSRNOP00000003010; -.
DR PaxDb; Q4V899; -.
DR PRIDE; Q4V899; -.
DR Ensembl; ENSRNOT00000003010; ENSRNOP00000003010; ENSRNOG00000002199.
DR GeneID; 364137; -.
DR KEGG; rno:364137; -.
DR CTD; 55858; -.
DR RGD; 1306983; Tmem165.
DR eggNOG; KOG2881; Eukaryota.
DR GeneTree; ENSGT00390000005261; -.
DR HOGENOM; CLU_040186_0_1_1; -.
DR InParanoid; Q4V899; -.
DR OMA; QGKWHSF; -.
DR OrthoDB; 919566at2759; -.
DR PhylomeDB; Q4V899; -.
DR TreeFam; TF105960; -.
DR PRO; PR:Q4V899; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Bgee; ENSRNOG00000002199; Expressed in stomach and 20 other tissues.
DR Genevisible; Q4V899; RN.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010008; C:endosome membrane; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0032588; C:trans-Golgi network membrane; ISS:UniProtKB.
DR GO; GO:0015085; F:calcium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; ISS:UniProtKB.
DR GO; GO:0032468; P:Golgi calcium ion homeostasis; IBA:GO_Central.
DR GO; GO:0032472; P:Golgi calcium ion transport; ISS:UniProtKB.
DR GO; GO:0071421; P:manganese ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006487; P:protein N-linked glycosylation; ISS:UniProtKB.
DR GO; GO:0035751; P:regulation of lysosomal lumen pH; ISS:UniProtKB.
DR InterPro; IPR001727; Gdt1.
DR PANTHER; PTHR12608; PTHR12608; 1.
DR Pfam; PF01169; UPF0016; 2.
DR PROSITE; PS01214; UPF0016; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Endosome; Golgi apparatus; Lysosome; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..323
FT /note="Transmembrane protein 165"
FT /id="PRO_0000247335"
FT TOPO_DOM 34..88
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..151
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..266
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..298
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..323
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REGION 35..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 184..211
FT /evidence="ECO:0000255"
SQ SEQUENCE 323 AA; 34810 MW; 4327C467BD29F3A3 CRC64;
MAASARGSGR APTRRLLVLL LLPLLWAPAG VRAGPEEDLS HRNQEPPAPA QQLQPQPAAV
QGLEPARAEK GFTPAAPVHT NREDAATQAN LGFIHAFVAA ISVIIVSELG DKTFFIAAIM
AMRYNRLTVL AGAMLALALM TCLSVLFGYA TTVIPRVYTY YVSTALFAIF GIRMLREGLK
MSPDEGQEEL EEVQAELKKK DEEFQRTKLL NGPDVETGTS TAIPQKKWLH FISPIFVQAL
TLTFLAEWGD RSQLTTIVLA AREDPYGVAV GGTVGHCLCT GLAVIGGRMI AQKISVRTVT
IIGGIVFLAF AFSALFISPE SGF
