ID   TM168_BOVIN             Reviewed;         697 AA.
AC   A0JNG0;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Transmembrane protein 168;
GN   Name=TMEM168;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM168 family. {ECO:0000305}.
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DR   EMBL; BC126667; AAI26668.1; -; mRNA.
DR   RefSeq; NP_001071499.1; NM_001078031.1.
DR   RefSeq; XP_015324709.1; XM_015469223.1.
DR   RefSeq; XP_015324713.1; XM_015469227.1.
DR   AlphaFoldDB; A0JNG0; -.
DR   STRING; 9913.ENSBTAP00000029286; -.
DR   PaxDb; A0JNG0; -.
DR   PRIDE; A0JNG0; -.
DR   Ensembl; ENSBTAT00000029286; ENSBTAP00000029286; ENSBTAG00000021967.
DR   GeneID; 541075; -.
DR   KEGG; bta:541075; -.
DR   CTD; 64418; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021967; -.
DR   VGNC; VGNC:35993; TMEM168.
DR   eggNOG; ENOG502QRB6; Eukaryota.
DR   GeneTree; ENSGT00390000005941; -.
DR   HOGENOM; CLU_032315_0_0_1; -.
DR   InParanoid; A0JNG0; -.
DR   OMA; HLANWFC; -.
DR   OrthoDB; 619817at2759; -.
DR   TreeFam; TF328518; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000021967; Expressed in oocyte and 105 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030133; C:transport vesicle; IEA:Ensembl.
DR   InterPro; IPR029713; TMEM168.
DR   PANTHER; PTHR14437; PTHR14437; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..697
FT                   /note="Transmembrane protein 168"
FT                   /id="PRO_0000284629"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        646..666
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        111
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        337
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        533
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        598
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   697 AA;  79785 MW;  D3EF6D7CEEC96CD8 CRC64;
     MCKSLRYCFS HCLYLAMTRL EEVNREVNMH SSVRYLGYLA RINLLVAICL GLYVRWEKTA
     NSLILVIFIL GLFVLGIASI LYYYFSMETA SLSLSNLWFG FLLGFLCFLD NSSFKNDVKE
     ESTKYLLLTS IVLRILCSLV ERMSGYVRHR PTLLTTVEFL ELVGFAIAST TMLVEKSLSV
     ILLVVALAML IIDLRMKSFL ALPNLVIFAV LLFFSSLETP KNPVAFACFF ICLITDPFLD
     IYFSGLSVTE RWKPFLYRGR ICRRLSVVFT GMIELTFFIL SAFKLRDTHL WYFVIPGFSI
     FGIFWMICHI IFLLTLWGFH TKLNDCHKVC FTHRVDNNSL DRIMASKGMR HFCLISEQLV
     FFSLLATAIL GAVSWQPTNG IFLSMFLIVL PLESMAHGLF HELGSCLGGT SVGYAIVIPT
     NFCSPDGQPT LLPPEHVQEL NLRSTGMLNA IQRFFAYHMI ETYGCDYSTS GLSFDTLHSK
     LKAFLELRTV DGPRHDTYVL YYSGHTHGTG EWALAGGDIL RLDTLLEWWR EKNGSFCSRL
     IIILDSENST PWVKEVRKIN DQYIAVQGAE MTKTIDIEEA DPPQLGDFTK DWVEYNCNTT
     NNICWTEKGR TVKAIYGVSK RWSDYTLHLP TGSDVAKHWM LYFPRITYPL VHLANWLCGL
     NLFWICKTCF RCLKRLKMSW FLPAVLDTGQ GFKLVKS