ID   TM168_PONAB             Reviewed;         697 AA.
AC   Q5RD28;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Transmembrane protein 168;
GN   Name=TMEM168;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM168 family. {ECO:0000305}.
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DR   EMBL; CR858090; CAH90329.1; -; mRNA.
DR   RefSeq; NP_001125154.1; NM_001131682.1.
DR   RefSeq; XP_009241432.1; XM_009243157.1.
DR   RefSeq; XP_009241433.1; XM_009243158.1.
DR   AlphaFoldDB; Q5RD28; -.
DR   STRING; 9601.ENSPPYP00000020089; -.
DR   Ensembl; ENSPPYT00000020881; ENSPPYP00000020089; ENSPPYG00000017920.
DR   GeneID; 100172041; -.
DR   KEGG; pon:100172041; -.
DR   CTD; 64418; -.
DR   eggNOG; ENOG502QRB6; Eukaryota.
DR   GeneTree; ENSGT00390000005941; -.
DR   HOGENOM; CLU_032315_0_0_1; -.
DR   InParanoid; Q5RD28; -.
DR   OMA; HLANWFC; -.
DR   OrthoDB; 619817at2759; -.
DR   TreeFam; TF328518; -.
DR   Proteomes; UP000001595; Chromosome 7.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030133; C:transport vesicle; IEA:Ensembl.
DR   InterPro; IPR029713; TMEM168.
DR   PANTHER; PTHR14437; PTHR14437; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..697
FT                   /note="Transmembrane protein 168"
FT                   /id="PRO_0000284632"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        646..666
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        111
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        533
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        598
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   697 AA;  79758 MW;  0354A3C4445FBC1B CRC64;
     MCKSLRYCFS HCLYLAMTRL EEVNREVNMH SSVRYLGYLA RINLLVAICL GLYVRWEKTA
     NSLILVIFIL GLFVLGIASI LYYYFSMEAA SLSLSNLWFG FLLGLLCFLD NSSFKNDVKE
     ESTKYLLLTS IVLRILCSLV ERISGYVRHR PTLLTTVEFL ELVGFAIAST TMLVEKSLSV
     ILLVVALAML IIDLRMKSFL AIPNLVIFTV LLFFSSLETP KNPIAFACFF ICLITDPFLD
     IYFSGLSVTE RWKPFLYRGR ICRRLSVVFA GMIELTFFIL SAFKLRDTHL WYFVIPGFSI
     FGIFWMICHI IFLLTLWGFH TKLNDCHKVY FTHRTDYSSL DRIMASKGMR HFCLISEQLV
     FFSLLATAIL GAVSWQPTNG IFLSMFLIVL PLESMAHGLF HELGNCLGGT SVGYAIVIPT
     NFCSPDGQPT LLPPEHVQEL NLRSTGMLNA IQRFFAYHMI ETYGCDYSTS GLSFDTLHSK
     LKAFLELRTV DGPRHDTYIL YYSGHTHGTG EWALAGGDTL RLDTLIEWWR EKNGSFCSRL
     IIVLDSENST PWVKEVRKIN DQYIAVQGAE LIKTVDIEEA DPPQLGDFTK DWVEYNCNSS
     NNICWTEKGR TVKAVYGVSK RWSDYTLHLP TGSDVAKHWM LHFPRITYPL VHLANWLCGL
     NLFWICKTCF RCLKRLKMSW FLPTVLDTGQ GFKLVKS